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Metabolomics1H-NMR metabolomics identifies hypoxanthine as a novel metastasis-associated metabolite
Breast cancer is one of the leading causes of death in females, mainly because of metastasis. Oncometabolites, produced via metabolic reprogramming, can influence metastatic signaling cascades. Accordingly, and based on our previous results, we hypothesized that metabolites from highly metastatic br...
2025-09-19 | MTBLS7764 | MetaboLights
MetabolomicsTFAM loss induces nuclear actin assembly upon mDia2 malonylation to promote liver cancer metastasis
The mechanisms underlying cancer metastasis remain poorly understood. Here, we report that TFAM deficiency rapidly and stably induced spontaneous lung metastasis in mice with liver cancer. Interestingly, unexpected polymerization of nuclear actin was observed in TFAM-knockdown HCC cells when cytoske...
2022-06-23 | MTBLS4307 | MetaboLights
MetabolomicsHyaluronan catabolism supports the peritoneal disseminated metastasis of cancer through the glucuronic acid pathway
When disseminated into the peritoneal cavity at the very early stage, cancer cells must adapt to the glucose- and oxygen-limited environment in peritoneal fluid, yet the key molecular regulators remain undefined. Here, we reveal that early disseminated OC cells are ingeniously utilize hyaluronic aci...
2026-07-10 | MTBLS15007 | MetaboLights
ProteomicsRNF185 control of COL3A1 expression limits prostate cancer migration and metastatic potential.
RNF185 is a RING finger domain-containing ubiquitin ligase implicated in ER-associated degradation. Prostate tumor patient data analysis revealed a negative correlation between RNF185 expression and prostate cancer progression and metastasis. Likewise, several prostate cancer cell lines exhibited gr...
ORGANISM(S): Mus musculus (Mouse) 
2024-08-09 | PXD045473 | Pride
Ubiquitin ligase  rnf185  prostate adenocarcinoma  metastasis  epithelial-mesenchymal transition (emt)  collagen 
TranscriptomicsDirect Signaling Between Platelets and Cancer Cells Induces an Epithelial-Mesenchymal-Like Transition and Promotes Metastasis
Interactions of cancer cells with the primary tumor microenvironment are important determinants of cancer progression towards metastasis but it is unknown whether additional prometastatic signals are provided during the intravascular transit to the site of metastasis. Here, we show that transient pl...
ORGANISM(S): Mus musculus 
2011-12-13 | E-GEOD-27456 | biostudies-arrayexpress
TranscriptomicsThe RON receptor tyrosine kinase promotes metastasis by triggering epigenetic reprogramming through the thymine glycosylase MBD4 (RNA-Seq)
Metastasis is the major cause of death in cancer patients, yet the genetic/epigenetic programs that drive metastasis are poorly understood. Here, we report a novel epigenetic reprogramming pathway that is required for breast cancer metastasis. Concerted differential DNA methylation is initiated by a...
ORGANISM(S): Homo sapiens 
2014-01-02 | E-GEOD-52687 | biostudies-arrayexpress
TranscriptomicsThe RON receptor tyrosine kinase promotes metastasis by triggering epigenetic reprogramming through the thymine glycosylase MBD4 (gene expression array)
Metastasis is the major cause of death in cancer patients, yet the genetic/epigenetic programs that drive metastasis are poorly understood. Here, we report a novel epigenetic reprogramming pathway that is required for breast cancer metastasis. Concerted differential DNA methylation is initiated by a...
ORGANISM(S): Homo sapiens 
2014-01-02 | E-GEOD-52567 | biostudies-arrayexpress
TranscriptomicsDifferentiation of Mammary Tumors and Reduction in Metastasis Upon Malat1 LncRNA Loss
Genome-wide analyses have identified thousands of long non-coding RNAs (lncRNAs). Malat1 (Metastasis Associated Lung Adenocarcinoma Transcript 1) is among the most abundant lncRNAs whose expression is altered in numerous cancers. Here we report that genomic loss, as well as systemic knockdown of Mal...
ORGANISM(S): Mus musculus 
2016-01-12 | E-GEOD-67647 | biostudies-arrayexpress
TranscriptomicsThe translational landscape of mTOR signaling steers cancer initiation and metastasis
The mammalian target of rapamycin (mTOR) kinase is a master regulator of protein synthesis that couples nutrient sensing to cell growth and cancer. However, the downstream translationally regulated nodes of gene expression that may direct cancer development are poorly characterized. Employing riboso...
ORGANISM(S): Homo sapiens 
2012-02-28 | E-GEOD-35469 | biostudies-arrayexpress
GenomicsAnalysis of paired primary and metastatic cell lines identifies common DNA methylation changes in melanoma metastasis.
Using 1 melanocyte and 6 melanoma cell line (3 pair of primary and metastatic), we generated base-resolution DNA methylation maps to document DNA methylation drivers of melanoma metastasis. Here we generated single-nucleotide resoultion DNA methylation map of a total of 7 cell lines using Reduced Re...
ORGANISM(S): Homo sapiens 
2017-05-17 | E-GEOD-70621 | biostudies-arrayexpress
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