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ProteomicsCarnitine palmitoyltransferase 1A promotes mitochondrial fission by enhancing MFF succinylation in ovarian cancer
Mitochondria are dynamic organelles that are important for cell growth and proliferation. Dysregulated mitochondrial dynamics are highly associated with the initiation and progression of various cancers, including ovarian cancer. However, the regulatory mechanism underlying mitochondrial dynamics is...
ORGANISM(S): Homo sapiens (Human) 
2023-05-15 | PXD041990 | Pride
Mitochondrial dynamics  mff  succinylation  ovarian cancer 
ProteomicsDelivery of MFF through mitochondria-derived vesicles regulates melanosome maturation
Melanosomes are lysosome-associated organelles that produce and accumulate melanin. Their biogenesis begins with the trafficking of melanogenic proteins from the endo-lysosomal system into non-pigmented vacuoles derived from endosomes. Subsequently, melanosome maturation proceeds with the export and...
ORGANISM(S): Mus musculus (Mouse) 
2026-05-25 | PXD051372 | Pride
Mitochondria Mff Melanosome 
GenomicsMFF marks a metabolic vulnerability of multiple myeloma
MFF marks a metabolic vulnerability of multiple myeloma
PRJNA1207479 | ENA
TranscriptomicsMFF marks a metabolic vulnerability of multiple myeloma
Increased mitochondrial fragmentation drives significant metabolic reprogramming that contributes to tumor progression. We explored the functional role of MFF (Mitochondrial Fission Factor), a key regulator of mitochondrial fragmentation, in the pathobiology of multiple myeloma (MM). MFF was found o...
ORGANISM(S): Homo sapiens 
2025-11-18 | GSE286009 | GEO
ProteomicsProteomic profile of MFF overexpression in MCF7 cells
Elevated mitochondrial biogenesis and metabolism represent key features of breast cancer stem cells (CSCs), whose propagation is conducive to disease onset and progression. Therefore, interfering with mitochondria biology and function may be regarded as a useful approach to eradicate CSCs. Here, we...
ORGANISM(S): Homo sapiens (Human) 
2020-10-16 | PXD020802 | Pride
Proteomics Mcf7 Breast cancer cells 
ProteomicsCPT1A-mediated MFF succinylation promotes stemness maintenance in ovarian cancer stem cells
Cancer stem cells (CSCs) play crucial roles in cancer progression, immune evasion, drug resistance, and recurrence. Understanding the mechanisms behind CSCs generation and stemness maintenance is vital for early cancer diagnosis and treatment. Here, we unveil that carnitine palmitoyltransferase 1A (...
ORGANISM(S): Homo sapiens (Human) 
2025-05-07 | PXD059026 | Pride
Mff Stemness maintenance Cpt1a Ovarian cancer stem cells Mams 
GenomicsMitochondrial Fission Factor (MFF) regulates mitochondrial Ca2+ homeostasis and neuronal activity in AgRP neurons
Mitochondrial Fission Factor (MFF) regulates mitochondrial Ca2+ homeostasis and neuronal activity in AgRP neurons
PRJNA1429310 | ENA
GenomicsRNA-seq profiling of Siniperca chuatsi MFF-1 cells under hypoxic conditions
RNA-seq profiling of Siniperca chuatsi MFF-1 cells under hypoxic conditions
PRJNA1423230 | ENA
GenomicsRNA-seq profiling of zinc sulfate-stimulated MFF-1 cells from Siniperca chuatsi
RNA-seq profiling of zinc sulfate-stimulated MFF-1 cells from Siniperca chuatsi
PRJNA1419314 | ENA
UnknownThe mitochondrial fission receptor Mff selectively recruits oligomerized Drp1.
Not available
S-EPMC4666140 | biostudies-literature
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