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Cancer stem cells (CSCs) play crucial roles in cancer progression, immune evasion, drug resistance, and recurrence. Understanding the mechanisms behind CSCs generation and stemness maintenance is vital for early cancer diagnosis and treatment. Here, we unveil that carnitine palmitoyltransferase 1A (...
ORGANISM(S): Homo sapiens (Human) 
2025-05-07 | PXD059026 | Pride
Role of Tubular Cpt1a in Aging Murine Kidneys
Role of Renal Tubule Cpt1a in Murine Kidneys
Endothelial cells (ECs) line the inner wall of blood vessels and maintain vascular stability. Vascular stability alteration is a hallmark of pathologies such as cancer and thrombosis. A role for fatty acid oxidation (FAO) in this process is unknown. Integrating MS-proteomics and metabolic modeling r...
ORGANISM(S): Homo sapiens (Human) 
2015-01-28 | PXD001186 | Pride
Ablation of Hepatic CPT1a Lowers Plasma Cholesterol Levels
Ablation of Hepatic CPT1a Lowers Plasma Cholesterol Levels.
One primary metabolic manifestation of inflammation is the diversion of cis-aconitate within the tricarboxylic acid (TCA) cycle to synthesize the immunometabolite itaconate. Itaconate is well established to possess immunomodulatory and metabolic effects within myeloid cells and lymphocytes, however,...
ORGANISM(S): Mus musculus (Mouse) 
2024-01-29 | PXD047706 | Pride
Hepatic CPT1A facilitates liver-adipose cross-talk via induction of FGF21
snRNAseq of Cpt1a-conditionally-depleted murine kidneys aged with high fat diet
Loss of CPT1a Modulates Phosphatidylethanolamine Levels Leading to Microvesicular Steatosis in Female Mice
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