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MetabolomicsProphylactic and therapeutic itaconate treatment alleviates COVID-19-associated lung injury

Although itaconate demonstrates anti-inflammatory and antimicrobial properties as an immunomodulatory metabolite, the therapeutic potential and mechanistic basis of vaccine-induced or prophylactic itaconate administration in COVID-19 intervention remains underexplored. Our studies reveal that int...

2025-08-06 | MTBLS12827 | MetaboLights
Metabolomics4-Octyl itaconate as a metabolite derivative inhibits inflammation via alkylation of STING

The Krebs cycle-derived metabolite itaconate, whose production is catalyzed by immune response gene 1 (IRG1), has excellent potential to link immunity and metabolism in activated macrophages through alkylation or competitive inhibition of target proteins. In support of this, our previous study de...

2023-01-15 | MTBLS5877 | MetaboLights
Metabolomics4-octyl itaconate inhibits aerobic glycolysis by targeting GAPDH to exert anti-inflammatory effects
Activated macrophages switch from oxidative phosphorylation to aerobic glycolysis, similar to the Warburg effect, presenting a potential therapeutic target in inflammatory disease. The endogenous metabolite itaconate has recently been reported to regulate macrophage function, but its precise mechani...
2019-10-02 | MTBLS1140 | MetaboLights
Proteomics,MultiomicsElectrophilic stress induced by itaconate and its derivatives regulates ATF3-IKBZ inflammatory axis independently of Nrf2 induction
Metabolic regulation recently emerged as a novel powerful principle guiding immune responses. The natural metabolite itaconate and its membrane permeable derivative dimethyl itaconate (DI) were recently shown to selectively inhibit a subset of cytokines during macrophage activation, yet the precise ...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2018-02-25 | MSV000082101 | MassIVE
ProteomicsValidation of itaconate modification on model proteins
This dataset was generated to confirm that +130 and +146 Da adducts observed in LPS-stimulated macrophages were produced by the itaconate metabolite. To this end, model proteins (bovine serum albumin and human KEAP1) were reacted in vitro with itaconate, and the correspondent adducts were analyzed b...
ORGANISM(S): Bos taurus (Bovine) Homo sapiens (Human) 
2021-07-22 | PXD019858 | Pride
Itaconate chemoproteomics mass spectrometry sampei adduct cysteine 
ProteomicsItaconate stabilizes CPT1a to enhance lipid utilization during inflammation
One primary metabolic manifestation of inflammation is the diversion of cis-aconitate within the tricarboxylic acid (TCA) cycle to synthesize the immunometabolite itaconate. Itaconate is well established to possess immunomodulatory and metabolic effects within myeloid cells and lymphocytes, however,...
ORGANISM(S): Mus musculus (Mouse) 
2024-01-29 | PXD047706 | Pride
Thermogenesis Itaconate Liver Sepsis Fatty acid metabolism 
TranscriptomicsItaconate links inhibition of succinate dehydrogenase with macrophage metabolic remodeling and regulation of inflammation
Remodeling of the tricarboxylic acid (TCA) cycle is a metabolic adaptation mechanism accompanying inflammatory macrophage activation. During this process, endogenous metabolites can adopt regulatory roles that govern specific aspects of inflammatory response, as recently shown for succinate, which r...
ORGANISM(S): Mus musculus 
2016-07-01 | E-GEOD-82043 | biostudies-arrayexpress
ProteomicsDiscovery of Itaconate-Mediated Lysine Acylation
Itaconate is an important anti-microbial and immunoregulatory metabolite involved in host-pathogen interactions. A key mechanistic action of itaconate is through the covalent modification of cysteine residues via Michael addition, resulting in “itaconation”. However, it is unclear whether itaconate ...
ORGANISM(S): Mus Musculus 
2023-02-28 | PXD040508 |
ProteomicsItaconate modulates immune responses via inhibition of peroxiredoxin 5
Wild type and Irg1 knockout mouse bone marrow derived macrophages (BMDMs) were processed with a redox proteomics workflow and analyzed by LC-MS/MS with TMT based quantification.
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2023-11-01 | MSV000093232 | MassIVE
ProteomicsThermal proteome profiling of itaconate interactome in macrophages
Thermal proteome profiling of itaconate in RAW 264.7 lysate
ORGANISM(S): Mus Musculus 
2025-02-11 | PXD060673 |
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