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To confirm how many and what kind of gene changes within 1 hour treatment of insulin stimulation, we have performed whole genome microarray expression profiling. And we found that 276 genes increased (>2 fold) or decreased (<0.5 fold) 10nM insulin induced gene expression in Fao cells was measured a...
ORGANISM(S): Rattus norvegicus 
Comprehensive identification of insulin-dependently changed genes in rat hepatoma FAO cells
Type 1 interferons (IFNs) induce complex responses that can be beneficial or deleterious, depending on context. Greater understanding of the mechanisms of action of these cytokines could allow new therapeutic approaches. We found that type 1 IFNs induced changes in cellular metabolism that were cr...
ORGANISM(S): Mus musculus 
HFD activated FAO mediates intestinal stemness and tumorgenicity I
HFD activated FAO mediates intestinal stemness and tumorgenicity II
Fluorescence detection of FAO activity with a chemical probe in cultured cells and mouse liver tissue
Even-chain acylcarnitine (AC) metabolites, most of which are generated as byproducts of incomplete fatty acid oxidation (FAO), are viewed as biomarkers of mitochondrial lipid stress attributable to one or more metabolic bottlenecks in the beta-oxidation pathway. The origins and functional implicatio...
ORGANISM(S): Mus Musculus (mouse) 
Obesity is an established risk factor for cancer in many tissues such as the gastrointestinal tract. In the mammalian intestine, a pro-obesity high fat diet (HFD) promotes tumorigenesis in part by enhancing intestinal stem cell (ISC) numbers, proliferation and function. Although Ppar (Peroxisome pro...
ORGANISM(S): Mus musculus 
2021-06-01 | GSE151046 | GEO
Obesity is an established risk factor for cancer in many tissues such as the gastrointestinal tract. In the mammalian intestine, a pro-obesity high fat diet (HFD) promotes tumorigenesis in part by enhancing intestinal stem cell (ISC) numbers, proliferation and function. Although Ppar (Peroxisome pro...
ORGANISM(S): Mus musculus 
2021-06-01 | GSE151045 | GEO
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