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ProteomicsA cross-disease human microglial framework identifies disease-enriched subsets and tool compounds for microglial polarization.
a. Human microglia play a pivotal role in neurological diseases, but few targeted therapies that directly modulate microglial state or function exist due to an incomplete understanding of microglial heterogeneity. We use single-cell RNA sequencing to profile live human microglia from autopsies or su...
ORGANISM(S): Homo sapiens (Human) 
2025-05-19 | PXD033844 | Pride
A. microglia  single-cell rna sequencing  neurodegeneration  neuroinflammation  disease-associated microglia  alzheimer’s  rnascope-immunofluorescence  microglial model systems  drug targets in neurodegeneration  camptothecin  diapasef  timstofpro 
TranscriptomicsMicroglial response to A? and prostaglandin-E2 EP4 receptor activation
A persistent and non-resolving inflammatory response to accumulating A? peptide species is a cardinal feature in the development of Alzheimer's disease (AD). In response to accumulating A? peptide species, microglia, the innate immune cells of the brain, generate a toxic inflammatory response that a...
ORGANISM(S): Mus musculus 
2014-04-25 | E-GEOD-55627 | biostudies-arrayexpress
TranscriptomicsMG400 profile of microglia from SOD miR155-KO mice
Amyotrophic lateral sclerosis (ALS) is a paralytic degenerative disease of the nervous system. In the SOD1 mouse model of ALS we found loss of the molecular and functional microglia signature associated with pronounced expression of miR-155 in SOD1 mice. We also found increased expression of miR-155...
ORGANISM(S): Mus musculus 
2014-11-24 | E-GEOD-52803 | biostudies-arrayexpress
ProteomicsR.norvegicus - Microglial cell, SC (Bell-temin,proteomics,2012)
abundance based on Spectral counting, Interaction consistency score: 20.2, Coverage: 25
ORGANISM(S): 10116 
2012-00-00 | 3360659913 | PAXDB
TranscriptomicsMicroglia treatment with C6 glioma-conditioned medium or with LPS
Several independent microglia preparations performed on different days were plated onto wells of 24-well plates, and either left untreated (control), treated with the C6 glioma-conditioned medium, or treated with LPS.
For each culture condition, a number of RNA samples were prepared, with each sa...
ORGANISM(S): Rattus norvegicus 
2012-12-14 | E-MEXP-2466 | biostudies-arrayexpress
TranscriptomicsMicroarray analysis to evaluate the function of USP18 in the mouse CNS
Microglia are tissue macrophages of the central nervous system (CNS) that control tissue homeostasis, and as such they are crucially important for organ integrity. Microglia dysregulation is thought to be causal for a group of neuropsychiatric, neurodegenerative and neuroinflammatory diseases, calle...
ORGANISM(S): Mus musculus 
2015-04-20 | E-GEOD-61499 | biostudies-arrayexpress
TranscriptomicsmiRNA profile in SOD-155 microglia
Amyotrophic lateral sclerosis (ALS) is a paralytic degenerative disease of the nervous system. In the SOD1 mouse model of ALS we found loss of the molecular and functional microglia signature associated with pronounced expression of miR-155 in SOD1 mice. We also found increased expression of miR-155...
ORGANISM(S): Mus musculus 
2014-11-24 | E-GEOD-52668 | biostudies-arrayexpress
TranscriptomicsmiR-155 plays a crucial role in ALS and is an immune therapeutic target [RNA-Seq]
Amyotrophic lateral sclerosis (ALS) is a paralytic degenerative disease of the nervous system. In the SOD1 mouse model of ALS we found loss of the molecular and functional microglia signature associated with pronounced expression of miR-155 in SOD1 mice. We also found increased expression of miR-155...
ORGANISM(S): Homo sapiens 
2014-11-24 | E-GEOD-52946 | biostudies-arrayexpress
TranscriptomicsDefining the microglia transcriptome during disease progression in ALS transgenic mice
Purpose: We purified spinal cord microglia utilizing percoll gradients and magnetic beads, followed by transcriptome profiling (RNA-seq) to define microglia expression profiles against other neural, immune cell-types. We next observed how the microglial transcriptomes change during activation in the...
ORGANISM(S): Mus musculus 
2013-07-15 | E-GEOD-43366 | biostudies-arrayexpress
UnknownMicroglial roles in Alzheimer's disease: An agent-based model to elucidate microglial spatiotemporal response to beta-amyloid.
Not available
S-EPMC10941569 | biostudies-literature
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