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MetabolomicsOsh2 mediates Candida resistance to miltefosine by regulating zymosterol transport
Miltefosine has been identified for its antifungal properties, yet the mechanisms underlying its action and the development of resistance remain unclear. In this study, we induced drug resistance in various Candida species through concentration gradient exposure, successfully obtaining a miltefosine...
2025-07-03 | MTBLS12270 | MetaboLights
TranscriptomicsComparison of gene expression of miltefosine responsive Vs miltefosine unresponsive Leishmania donovani promastigotes
The current study aims to study change in gene expression profile of miltefosine resistance L. donovani with respect to miltefosine responsive L. donovani. Agilent one-color experiment,Organism: Leishmania donovani, Microarray GeneExpression 8x15k designed by Genotypic Technology Private Limited. (A...
ORGANISM(S): Leishmania donovani 
2013-08-05 | E-GEOD-45496 | biostudies-arrayexpress
ProteomicsIn-depth proteomics analysis of a Leishmania infantum strain selected in vitro for miltefosine resistance
Visceral Leishmaniasis (VL) is a neglected disease caused Leishmania parasites. Although significant morbidity and mortality in tropical and subtropical regions of the world are associated to VL, low investment for developing new treatment measures is chronic. Moreover, resistance and treatment fail...
ORGANISM(S): Leishmania infantum 
2022-05-20 | PXD031912 | Pride
Tca cycle Atp synthase. Fatty acid β-oxidation Cytochrome c oxidase Leishmania infantum  miltefosine resistance  quantitative proteomics  fasp  mass spectrometry  oxidative phosphorylation 
MetabolomicsAmphotericin B resistance in Leishmania mexicana: Alterations to sterol metabolism, lipid transport and oxidative stress response

Amphotericin B is increasingly used in treatment of leishmaniasis. Here, fourteen independent lines of Leishmania mexicana and one L. infantum line were selected for resistance to either amphotericin B or the related polyene antimicrobial, nystatin. Sterol profiling revealed tha...

2022-09-22 | MTBLS2744 | MetaboLights
GenomicsL. chagasi Miltefosine Resistance
Study of Natural Miltefosine-Resistance Mechanism in Leishmania (L.) chagasi Isolates from Visceral Leishmaniasis Patients with Different Treatment Outcomes
PRJEB14694 | ENA
TranscriptomicsComparison of gene expression of miltefosine responsive Vs miltefosine unresponsive Leishmania donovani promastigotes
The current study aims to study change in gene expression profile of miltefosine resistance L. donovani with respect to miltefosine responsive L. donovani.
ORGANISM(S): Leishmania donovani 
2013-08-05 | GSE45496 | GEO
GenomicsThe role of Aspergillus fumigatus SmiA transcription factor in the miltefosine resistance
The role of Aspergillus fumigatus SmiA transcription factor in the miltefosine resistance
PRJNA739977 | ENA
GenomicsThe role of Aspergillus fumigatus SmiA transcription factor in the miltefosine resistance
By searching for new drugs against fungal pathogens, we found that miltefosine is active against Aspergillus fumigatus clinical isolates. A library of transcription factors (TF) null mutants was then challenged with this drug and we discovered a novel TF that confers resistance to miltefonise, named...
ORGANISM(S): Aspergillus fumigatus 
2021-08-23 | GSE178664 | GEO
TranscriptomicsIdentification of biomarkers for Miltefosine resistance in Leishmania donovani
To identify biomarkers specific for Miltefosin resistant parasites, we used DNA microarray to identify differentially expressed genes in resistant parasite in comparision to sensitive and further validated with real time PCR assay and immunoblotting assay Clinically proven miltefosine reistant as we...
ORGANISM(S): Leishmania donovani 
2014-01-31 | E-GEOD-53738 | biostudies-arrayexpress
UnknownSitamaquine overcomes ABC-mediated resistance to miltefosine and antimony in Leishmania.
Not available
S-EPMC3147638 | biostudies-literature
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