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MetabolomicsRibosomal mistranslation leads to silencing of the unfolded protein response and increased mitochondrial biogenesis

Translation fidelity is the limiting factor in the accuracy of gene expression. With an estimated frequency of 10-4, errors in mRNA decoding occur in a mostly stochastic manner. Little is known about the response of higher eukaryotes to chronic loss of ribosomal accuracy as per an increase in the...

2019-09-17 | MTBLS106 | MetaboLights
TranscriptomicsTo analyze the effect of loss of mitochondria on the transcriptome of Candida albicans
This set of experiment was done in order to analyze the effect of a dysfunctional mitochondria on C. albicans. The mutant was obtained by deleting the gene FZO1, which is known to be involved in mitochondrial biogenesis in S. cerevisiae. We show that the deletion of FZO1 leads to a change in mitocho...
ORGANISM(S): Candida albicans 
2013-12-05 | E-GEOD-46003 | biostudies-arrayexpress
GenomicsDaedalus and Gasz recruit Armitage to mitochondria, bringing piRNA precursors to the biogenesis machinery
Daedalus and Gasz recruit Armitage to mitochondria, bringing piRNA precursors to the biogenesis machinery
PRJNA530959 | ENA
UnknownER-mitochondria contacts promote mitochondrial-derived compartment biogenesis.
Not available
S-EPMC7588143 | biostudies-literature
TranscriptomicsLooking for mitochondrial associated RNA
We investigated the peripheral mitochondrial localization of nuclear-encoded mRNAs (MLR) in various conditions in which translation was inhibited or the mRNA binding protein context altered (Delta puf3). We used cell fractionation protocols together with microarray to assess the distribution of mRNA...
ORGANISM(S): Saccharomyces cerevisiae 
2008-06-01 | E-GEOD-9393 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of differentiated brown adipocytes from wild type, PGC-1 alpha knockout, or PGC-1 alpha knockout and PGC-1 beta knockdown mice to investigate the roles of PGC-1 coactivators in brown fat differentiation.
Mitochondria play an essential role in the ability of brown fat to generate heat, and the PGC-1 coactivators control several aspects of mitochondrial biogenesis. To investigate their specific roles in brown fat cells, we generated immortal preadipocyte lines from the brown adipose tissue of mice lac...
ORGANISM(S): Mus musculus 
2007-11-27 | E-GEOD-5042 | biostudies-arrayexpress
UnknownArginine methylation of SIRT7 couples glucose sensing with mitochondria biogenesis.
Not available
S-EPMC6280788 | biostudies-literature
ProteomicsDaedalus and Gasz recruit Armitage to mitochondria, bringing piRNA precursors to the biogenesis machinery
The piRNA pathway is a small RNA-based immune system that silences mobile genetic elements in animal germlines. piRNA biogenesis requires a specialised machinery that converts long single-stranded precursors into small RNAs of ~25-nucleotides in length. This process involves factors that operate in ...
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2019-04-18 | PXD013403 | Pride
Pirna piwi drosophila 
ProteomicsDaedalus and Gasz recruit Armitage to mitochondria, bringing piRNA precursors to the biogenesis machinery
The piRNA pathway is a small RNA-based immune system that silences mobile genetic elements in animal germlines. piRNA biogenesis requires a specialised machinery that converts long single-stranded precursors into small RNAs of ~25-nucleotides in length. This process involves factors that operate in ...
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2019-04-18 | PXD013405 | Pride
Pirna piwi drosophila 
ProteomicsDaedalus and Gasz recruit Armitage to mitochondria, bringing piRNA precursors to the biogenesis machinery
The piRNA pathway is a small RNA-based immune system that silences mobile genetic elements in animal germlines. piRNA biogenesis requires a specialised machinery that converts long single-stranded precursors into small RNAs of ~25-nucleotides in length. This process involves factors that operate in ...
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2019-04-18 | PXD013404 | Pride
Pirna piwi drosophila 
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