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MetabolomicsOPA1 promotes ferroptosis by augmenting mitochondrial ROS and suppressing an integrated stress response

Ferroptosis, an iron-dependent form of nonapoptotic cell death mediated by lipid peroxidation, has been implicated in the pathogenesis of multiple diseases. Subcellular organelles play pivotal roles in the regulation of ferroptosis, but the mechanisms underlying the contributions of the mitochond...

2025-07-14 | MTBLS10544 | MetaboLights
GenomicsAltered Cardiac Energetics and Mitochondrial Dysfunction in Hypertrophic Cardiomyopathy
Altered Cardiac Energetics and Mitochondrial Dysfunction in Hypertrophic Cardiomyopathy
PRJNA747806 | ENA
GenomicsEffect of Aging on Mitochondrial Energetics in the Human Atria
Effect of Aging on Mitochondrial Energetics in the Human Atria
PRJNA726259 | ENA
TranscriptomicsAltered Cardiac Energetics and Mitochondrial Dysfunction in Hypertrophic Cardiomyopathy
Hypertrophic cardiomyopathy (HCM) is a complex disease partly explained by the effects of individual gene variants on sarcomeric protein biomechanics. At the cellular level, HCM mutations most commonly enhance force production, leading to higher energy demands. Despite significant advances in elucid...
ORGANISM(S): Homo sapiens 
2022-07-17 | GSE180313 | GEO
TranscriptomicsTranscriptomic analysis of human cybrid cell lines harboring increasing levels of the mitochondrial DNA (mtDNA) 3243A>G mutation
Mitochondria generate signals of adaptation that regulate nuclear genes expression via retrograde signaling. But this phenomenon is complexified when qualitatively different mitochondria and mitochondrial DNA (mtDNA) coexist within cells. Although this cellular state of heteroplasmy leads to diver...
ORGANISM(S): Homo sapiens 
2014-09-02 | E-GEOD-56158 | biostudies-arrayexpress
GenomicsImpaired RPE Mitochondrial Energetics Leads Subretinal Fibrosis in Neovascular Age-related Macular Degeneration
Impaired RPE Mitochondrial Energetics Leads Subretinal Fibrosis in Neovascular Age-related Macular Degeneration
PRJNA916923 | ENA
ProteomicsFAK modulates glioblastoma stem cell energetics via actomyosin contractility: regulation of glycolysis and mitochondrial function
Glycolysis and the TCA cycle are commonly reprogrammed to fulfil the bioenergetic and biosynthetic demands of cancer cells. Although the extracellular matrix is known to influence glycolysis and the TCA cycle, it is not well understood how specific adhesion proteins and their downstream effectors c...
ORGANISM(S): Mus musculus (Mouse) 
2025-12-15 | PXD058998 | Pride
Fak Metabolims 
UnknownHistone methyltransferase Smyd1 regulates mitochondrial energetics in the heart.
Not available
S-EPMC6099878 | biostudies-literature
UnknownAltered Cardiac Energetics and Mitochondrial Dysfunction in Hypertrophic Cardiomyopathy.
Not available
S-EPMC8608736 | biostudies-literature
GenomicsTMEM97 is A Cholesterol Sensing Onco-Protein and Sustains Mitochondrial Energetics Through Lipid Biosynthesis
TMEM97 is A Cholesterol Sensing Onco-Protein and Sustains Mitochondrial Energetics Through Lipid Biosynthesis
PRJNA1375822 | ENA
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