Irinotecan (CPT-11) is widely used for colorectal cancer treatment, with delayed-onset diarrhea as its primary side effect. Xiao-Chai-Hu-Tang (XCHT) has been clinically observed to alleviate diarrhea, but its mechanisms remain unclear. This study aimed to explore the underlying regulatory mechani...
Focal adhesion kinase (FAK) is a non-receptor tyrosine kinase that plays an important role in proliferation, motility, adhesion, invasion, angiogenesis, and survival signaling. Focal adhesion kinase has been shown to be overexpressed in many types of tumors, including breast cancer at early stages o...
Human foreskin fibroblast cells were spread on fibronectin (FN) for 1 h and treated with DMSO or FAK inhibitor (3 uM, AZ13256675 (termed AZ675 for short)) for 1 h. Integrin-associated adhesion complexes isolated from these cells were analysed by mass spectrometry to determine changes in adhesion com...
CMV-driven FAK overexpression in soleus muscle was compared vs empty transfection in contralateral muscle after 1 day of reloading paired comparison in contralateral leg
Precise vascular patterning is critical for normal growth and development. The ERG transcription factor drives Delta like ligand 4 (DLL4)/Notch signalling and is thought to act as pivotal regulators of endothelial cell (EC) dynamics and developmental angiogenesis. However, molecular regulation of E...
This SuperSeries is composed of the following subset Series: GSE12743: pCMV-FAK vs pCMV in CTL GSE12744: pCMV-FRNK/pCMV-FAK vs pCMV-FAK in CTL GSE12745: pCMV-FAK vs pCMV in HU GSE12746: pCMV-FAK vs pCMV in R1 GSE12747: pCMV-FAK vs pCMV in R5 Refer to individual Series
CMV-driven FAK overexpression in soleus muscle was compared vs empty transfection in contralateral muscle after unloading paired comparison in contralateral leg
CMV-driven FAK overexpression in soleus muscle was compared vs empty transfection in contralateral muscle after 5 day of reloading paired comparison in contralateral leg
Endothelin-1 (ET-1) plays a critical role in connective tissue remodeling by fibroblasts during tissue repair and fibrosis. We investigated the molecular pathways in the transmission of ET-1 signals that lead to features of connective tissue remodeling, in particular the role of FAK (focal adhesion ...
Here, using mouse squamous cell carcinoma cells, we report a completely new function for the autophagy protein Ambra1 as the first described ‘spatial rheostat’ controlling the Src/FAK pathway. Ambra1 regulates the targeting of active phospho-Src away from focal adhesions into autophagic structures t...
