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ProteomicsSmall heat shock proteins operate as molecular chaperones in the mitochondrial intermembrane space
Mitochondria are complex organelles with different compartments, each harboring their own protein quality control factors. While the chaperones of the mitochondrial matrix have been well characterized, it is poorly understood which chaperones protect the mitochondrial intermembrane space. We show th...
ORGANISM(S): Homo sapiens (Human) 
2022-12-12 | PXD038275 | Pride
Charcot-marie-tooth (cmt) disease Protein quality control Intermembrane space Small heat shock proteins Mitochondria Chaperones 
UnknownRetro-translocation of mitochondrial intermembrane space proteins.
Not available
S-EPMC4485110 | biostudies-literature
TranscriptomicsComparative analysis of transcripts from mia40-4int mutant and wild-type Saccharomyces cerevisiae strains quantified in RNA-seq experiment
The vast majority of the mitochondrial proteome originates from nuclear genes and is transported into the organelle after synthesis in the cytosol. Complex machineries, which maintain the specificity of protein import and sorting exist. Dysfunctions of mitochondrial protein sorting pathways result i...
ORGANISM(S): Saccharomyces cerevisiae 
2015-07-31 | E-MTAB-3588 | biostudies-arrayexpress
ProteomicsDysfunctional mitochondria trap proteins in the intermembrane space - Data set 5: MRP17 - AP-MS
Mitochondria consist of hundreds of proteins which are initially synthesized in the cytosol as ‘precursors’ and imported into the organelle. The accumulation of precursors in the cytosol due to mitochondrial dysfunction compromises cellular proteostasis and is a hallmark of diseases. How cells count...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) Saccharomyces cerevisiae (Baker's yeast) 
2025-05-21 | PXD054381 | Pride
Yeast mitochondrial import 
ProteomicsDysfunctional mitochondria trap proteins in the intermembrane space - Data set 1: proximity labelling
Mitochondria consist of hundreds of proteins which are initially synthesized in the cytosol as ‘precursors’ and imported into the organelle. The accumulation of precursors in the cytosol due to mitochondrial dysfunction compromises cellular proteostasis and is a hallmark of diseases. How cells count...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2025-05-21 | PXD057245 | Pride
Mitochondria Yeast 
UnknownMammalian mitochondrial RNAs are degraded in the mitochondrial intermembrane space by RNASET2.
Not available
S-EPMC5636749 | biostudies-literature
ProteomicsMapping the protein interactome of mitochondrial intermembrane space proteases identifies a novel function for HTRA2
Data contains LC-MS data of proximity-based biotin labeling assay (BioID) to generate the protein interaction network of mitochondrial intermembrane space proteases fused with BirAFlag (C-terminal tag) and expressed in T-REx HEK293 cells.
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2018-11-14 | MSV000083140 | MassIVE
UnknownSOD1 targeted to the mitochondrial intermembrane space prevents motor neuropathy in the Sod1 knockout mouse.
Not available
S-EPMC3009841 | biostudies-literature
ProteomicsDysfunctional mitochondria trap proteins in the intermembrane space - Data set 4: AP-MS for Apj1, Pwp2 and Utp18
Mitochondria consist of hundreds of proteins which are initially synthesized in the cytosol as ‘precursors’ and imported into the organelle. The accumulation of precursors in the cytosol due to mitochondrial dysfunction compromises cellular proteostasis and is a hallmark of diseases. How cells count...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2025-05-21 | PXD062600 | Pride
Mitochondria Yeast 
UnknownMitochondrial biogenesis, switching the sorting pathway of the intermembrane space receptor Mia40.
Not available
S-EPMC2662054 | biostudies-literature
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