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ProteomicsAMPK activation promotes transcriptional activation of TFEB through its dephosphorylation
Transcription Factor EB (TFEB) is a critical regulator of lysosomal biogenesis, autophagy and energy homeostasis through regulating expression of genes belonging to the Coordinated Lysosomal Expression and Regulation network. Recently, AMP-activated protein kinase (AMPK) was reported to phosphorylat...
ORGANISM(S): Mus musculus (Mouse) 
2026-02-11 | PXD055410 | Pride
Bay-3827  coordinated lysosomal expression and regulation  mk-8722  reversible phosphorylation  mtor  tfe3 
TranscriptomicsPan-ampk activation improves renal function in a rat model of progressive diabetic nephropathy
Chronic kidney disease (CKD) remains a tremendous and growing burden on the healthcare system and new therapies are needed to prevent or slow disease progression. Metabolic dysregulation and mitochondrial dysfunction are important features of acute and chronic tissue injury across species, and human...
ORGANISM(S): Rattus norvegicus 
2019-07-25 | GSE134804 | GEO
TranscriptomicsAMPK promotes TFEB transcriptional activity through dephosphorylation at both mTORC1-dependent and -independent sites [dataset 2]
TFEB (transcription factor EB) is a critical regulator of lysosomal biogenesis, macroautophagy/autophagy and energy homeostasis through controlling expression of genes belonging to the coordinated lysosomal expression and regulation network. AMP-activated protein kinase (AMPK) has been reported to p...
ORGANISM(S): Mus musculus 
2026-02-11 | GSE270825 | GEO
TranscriptomicsAMPK promotes TFEB transcriptional activity through dephosphorylation at both mTORC1-dependent and -independent sites [dataset 1]
TFEB (transcription factor EB) is a critical regulator of lysosomal biogenesis, macroautophagy/autophagy and energy homeostasis through controlling expression of genes belonging to the coordinated lysosomal expression and regulation network. AMP-activated protein kinase (AMPK) has been reported to p...
ORGANISM(S): Mus musculus 
2026-02-11 | GSE270824 | GEO
TranscriptomicsMechanism and cellular actions of the potent AMPK inhibitor BAY-3827
Inhibition of AMP-activated protein kinase (AMPK) is increasingly being explored for its therapeutic potential in some diseases, including certain types of cancers. However, AMPK-inhibitory tool compounds have largely been limited to compound C/dorsomorphin and SBI-0206965, both of which display num...
ORGANISM(S): Mus musculus 
2025-07-28 | GSE290022 | GEO
UnknownCommon and distinct roles of AMPKγ isoforms in small-molecule activator-stimulated glucose uptake in mouse skeletal muscle.
Not available
S-EPMC12757550 | biostudies-literature
UnknownDirect pharmacological AMPK activation inhibits mucosal SARS-CoV-2 infection by reducing lipid metabolism, restoring autophagy flux and the type I IFN response.
Not available
S-EPMC12282067 | biostudies-literature
UnknownAMPK protects endothelial cells against HSV-1 replication via inhibition of mTORC1 and ACC1.
Not available
S-EPMC10580915 | biostudies-literature
UnknownMechanism and cellular actions of the potent AMPK inhibitor BAY-3827.
Not available
S-EPMC12372887 | biostudies-literature
TranscriptomicsMetabolic dysfunction is integral to TGFb signaling and tissue fibrosis
Fibrosis, or the accumulation of extracellular matrix, causes loss of organ function and is a common feature of many chronic diseases. To interrogate core molecular pathways underlying fibrosis, we cross–examine human primary cells from various tissues treated with TGFβ, as well as rodent kidney and...
ORGANISM(S): Homo sapiens Mus musculus Rattus norvegicus 
2020-11-24 | GSE152250 | GEO
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