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TranscriptomicsMessenger RNA expression after MK2206/DMSO treatment of T47D cells
We performed RNA-seq in T47D cells after 24 hour treatment with the AKT inhibitor MK2206 or DMSO. We show that a group of transcripts is differentailly expressed after AKT inhibition. Comparison of mRNA levels using RNA-seq after AKT inhibition vs vehicle
ORGANISM(S): Homo sapiens 
2016-06-14 | E-GEOD-80591 | biostudies-arrayexpress
GenomicsGenome-wide H3K4me3 after MK2206/DMSO treatment of T47D cells
We perfomed ChIP-seq using H3K4me3 antibodies in T47D cells after 24 hour treatment with the AKT inhibitor MK2206 or DMSO. We demonstrate that at a selected group of loci H3K4me3 is affected by AKT inhibition. Comparison of genome-wide H3K4me3 binding after AKT inhibition vs vehicle
ORGANISM(S): Homo sapiens 
2016-06-14 | E-GEOD-80592 | biostudies-arrayexpress
GenomicsGenome-wide KDM5A occupancy after MK2206/DMSO treatment of T47D cells
We perfomed ChIP-seq using KDM5A antibodies in T47D cells after 24 hour treatment with the AKT inhibitor MK2206 or DMSO. We show that the cistrome of the H3K4 demethylase KDM5A is affected by AKT inhibition. Comparison of genome-wide KDM5A binding after AKT inhibition vs vehicle
ORGANISM(S): Homo sapiens 
2016-06-14 | E-GEOD-80593 | biostudies-arrayexpress
TranscriptomicsAkt inhibitor MK2206 prevents influenza A(H1N1)pdm09 virus infection in vitro
The influenza A(H1N1)pdm09 virus caused a global flu pandemic in 2009 and contributes to seasonal epidemics. Different treatment and prevention options for influenza have been developed and applied with limited success. Here we report that an Akt inhibitor MK2206 possesses potent antiviral activity ...
ORGANISM(S): Homo sapiens 
2014-01-23 | E-GEOD-54293 | biostudies-arrayexpress
TranscriptomicsAkt inhibitor MK2206 prevents influenza A(H1N1)pdm09 virus infection in vitro
The influenza A(H1N1)pdm09 virus caused a global flu pandemic in 2009 and contributes to seasonal epidemics. Different treatment and prevention options for influenza have been developed and applied with limited success. Here we report that an Akt inhibitor MK2206 possesses potent antiviral activity ...
ORGANISM(S): Homo sapiens 
2014-01-23 | GSE54293 | GEO
GenomicsRNA-seq analysis of AKTi MK2206 resistant BT474 and T47D cells
RNA-seq analysis of AKTi MK2206 resistant BT474 and T47D cells
PRJNA484709 | ENA
UnknownAkt inhibitor MK2206 prevents influenza pH1N1 virus infection in vitro.
Not available
S-EPMC4068572 | biostudies-literature
UnknownMK2206 attenuates atherosclerosis by inhibiting lipid accumulation, cell migration, proliferation, and inflammation.
Not available
S-EPMC8976090 | biostudies-literature
TranscriptomicsMessenger RNA expression after MK2206/DMSO treatment of T47D cells
We performed RNA-seq in T47D cells after 24 hour treatment with the AKT inhibitor MK2206 or DMSO. We show that a group of transcripts is differentailly expressed after AKT inhibition.
ORGANISM(S): Homo sapiens 
2016-06-14 | GSE80591 | GEO
GenomicsGenome-wide H3K4me3 after MK2206/DMSO treatment of T47D cells
We perfomed ChIP-seq using H3K4me3 antibodies in T47D cells after 24 hour treatment with the AKT inhibitor MK2206 or DMSO. We demonstrate that at a selected group of loci H3K4me3 is affected by AKT inhibition.
ORGANISM(S): Homo sapiens 
2016-06-14 | GSE80592 | GEO
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