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ProteomicsPIP2 promotes MLKL-derived pathogenic process through enhancing its channel activity
PIP2 enhances MLKL channel activity in a direct interaction manner and this gain of function promotes both necroptosis and inflammation. Previous studies have reported that phospholipids assisted MLKL recruitment and translocation which facilitates its mediated function like liposome leaking. Here, ...
ORGANISM(S): Mus musculus (Mouse) 
2022-11-05 | PXD030814 | Pride
Bv2 lps mlkl lc/msms pip2 
ProteomicsOligomerisation-driven MLKL ubiquitylation antagonises necroptosis
Mixed lineage kinase domain-like (MLKL) is the executioner in the caspase 8-independent form of programmed cell death called necroptosis. Once Receptor Interacting serine/threonine Protein Kinase 3 (RIPK3) is activated by upstream cell death signals, it phosphorylates MLKL and triggers the oligomeri...
ORGANISM(S): Mus musculus (Mouse) 
2021-04-28 | PXD015537 | Pride
Ubiquitylation Oligomerisation Membranes Necroptosis Mlkl 
GenomicsSingle cell RNA-seq of intestine from E18.5 Mlkl -/- and Casp8 C362A/C362A Mlkl -/- embryos
Single cell RNA-seq of intestine from E18.5 Mlkl -/- and Casp8 C362A/C362A Mlkl -/- embryos
PRJNA546000 | ENA
GenomicsCASP8 C362A KI MLKL KO e16.5 intestine RNAseq
CASP8 C362A KI MLKL KO e16.5 intestine RNAseq
PRJNA516934 | ENA
GenomicsRNA-sequencing of control (CTL), MLKL -/- (MLKL) and RIPK3-/- (RIPK3) 3T3-L1 preadipocytes (J0) or differentiated (J7) cells.
RNA-sequencing of control (CTL), MLKL -/- (MLKL) and RIPK3-/- (RIPK3) 3T3-L1 preadipocytes (J0) or differentiated (J7) cells.
PRJNA831810 | ENA
ProteomicsDiscovery of Novel MLKL PROTAC Degrader for the Treatment of Hepatocellular Carcinoma via Promoting Parthanatos
Chen et al. discovered a highly potent and selective MLKL-targeted PROTAC C116 that effectively induces MLKL degradation and promotes parthanatos in HCC cells. More significantly, C116 was able to induce in vivo MLKL degradation and exerts anti-tumor activities in an orthotopic HCC tumor model, posi...
ORGANISM(S): Mus Musculus 
PXD069462 |
ProteomicsNociceptive neurons inhibit neutrophil extracellular trap formation via MLKL-licensed histone release
This data set contains the raw data of proteinomic analysis of dorsal root ganglions (DRGs) in WT and MLKL-KO mice under basal condition and after CFA treatment, and MLKL-based IP-MS analysis of WT DRGs under basal condition and after CFA treatment.
ORGANISM(S): Mus Musculus 
PXD077273 |
ProteomicsThe critical role of MLKL in hemorrhagic stroke and the therapeutic potential of its associated protein network
MLKL, as the executor of necroptosis and a critical factor in the inflammation, has been shown to be associated with the progression of hemorrhagic stroke. Studies identified MLKL is a promoting factor in this process, suggesting its potential as a therapeutic target to mitigate post-hemorrhagic str...
ORGANISM(S): Mus Musculus 
PXD056595 |
GenomicsMLKL associated with angiogenesis and osteolysis in periapical lesions
MLKL associated with angiogenesis and osteolysis in periapical lesions
PRJNA1031590 | ENA
ProteomicsQuantitative Proteomic and Phosphoproteomic Analyses of MLKL -/- mouse heart in response to influenza virus infection
Influenza virus infection leads to global cardiac proteome remodeling during convalescence MTD project_description "Influenza virus infections lead to more than 500,000 hospitalizations in the U.S. every year. Patients with cardiovascular diseases have been shown to be at high risk of influenza medi...
ORGANISM(S): Mus musculus (Mouse) 
2022-04-01 | PXD017936 | Pride
Quantitative proteomics  phosphoproteomics  phosphorylation  heart  mlkl 
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