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The aim of this study is to analyze the distribution of the modified histones in and around peri-centromeric heterochromatin at high resolutions for understanding the molecular nature of the heterochromatic genes and euchromatin-heterochromatin transition. Since heterochromatin is repeat-rich, strin...
ORGANISM(S): Drosophila melanogaster 
MCM2 promotes symmetric inheritance of modified histones during DNA replication
A library of unmodified and differentially modified human histones H3 and H4 was prepared using native chemical ligation as described previously (Bartke et al., 2010; Nakamura et al., 2019). The modification status of histone H3 and H4 products was confirmed by LC-MS/MS.
ORGANISM(S): Homo sapiens (Human) 
2023-12-10 | PXD020773 | Pride
Trypanosomes diverged from the main eukaryotic lineage about 600 million years ago, and display some unusual genomic and epigenetic properties that provide valuable insight into the early processes employed by eukaryotic ancestors to regulate chromatin-mediated functions. We sequenced Trypanosoma br...
ORGANISM(S): Trypanosoma brucei 
2022-08-21 | PXD024574 | Pride
The aim of this study is to analyze the distribution of the modified histones in and around peri-centromeric heterochromatin at high resolutions for understanding the molecular nature of the heterochromatic genes and euchromatin-heterochromatin transition. Keywords: ChIP-chip
ORGANISM(S): Drosophila melanogaster 
2008-01-28 | GSE7839 | GEO
During genome replication, parental histones are recycled to newly replicated DNA with their post-translational modifications (PTMs). It remains unknown whether sister chromatids inherit modified histones evenly. Here, we measured histone PTM partition to sister chromatids in embryonic stem cells. W...
ORGANISM(S): Mus musculus 
2018-08-16 | GSE117274 | GEO
Dynamic histone post-translational modifications are crucial to precisely orchestrate gene expression programs. The recently discovered histone lysine lactylation has already been explored in various pathological contexts, but less in normal tissues. This modification exists as two enantiomers, L- a...
ORGANISM(S): Mus musculus (Mouse) 
2026-07-01 | PXD070921 | Pride
Trypanosoma brucei histones are heavily modified with combinatorial post-translational modifications and mark Pol II transcription start regions with hyperacetylated H2A.
Molecular landscape of modified histones in Drosophila heterochromatin
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