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MetabolomicsMetabolomics analysis of the algU mutant strain under hyperosmotic stress.
Metabolomics analysis of the algU mutant strain under hyperosmotic stress.
2024-07-12 | MTBLS9769 | MetaboLights
MetabolomicsLC-MS-based metabolomic analysis of Vd991 and VdGGCT knockout mutant strains
This study aimed to identify differentially expressed metabolites between Vd991 and VdGGCT knockout mutant strains using liquid chromatography-mass spectrometry (LC-MS). A total of 6 samples, including both Vd991 and VdGGCT knockout mutant groups, were analyzed to explore metabolic changes and disco...
2026-05-11 | MTBLS14397 | MetaboLights
MetabolomicsLC-MS based untargeted metabolomics of muscle in GMPPB mutant mice
Muscle tissues from GMPPB mutant mouse model and control mice were collected, untargeted metabolomics was performed via LC-MS (positive/negative HILIC), differential metabolites were identified to explore the mechanismof GMPPB in muscular dystrophy.
2026-02-03 | MTBLS10214 | MetaboLights
MetabolomicsMulti-omics characterization of acquired Olaparib resistance in BRCA1 and BRCA2 mutant breast cancer cell lines
Poly (ADP-ribose) polymerase inhibitors (PARPi) are widely used as targeted therapies against breast cancers with BRCA mutations. However, the development of resistance to PARPi poses a significant challenge for long-term efficacy of these therapies, warranting further understanding of mechanisms of...
2026-05-11 | MTBLS12109 | MetaboLights
MetabolomicsMitochondrial metabolism sustains DNMT3A-R882-mutant clonal haematopoiesis
Somatic DNMT3A R882 codon mutations drive the most common form of clonal haematopoiesis (CH) and are associated with increased acute myeloid leukaemia (AML) risk1,2. Preventing expansion of DNMT3A-R882-mutant haematopoietic stem/progenitor cells (HSPCs) may therefore avert progression to AML. To ide...
2025-02-06 | MTBLS12201 | MetaboLights
MetabolomicsCholesterol dysregulation contributes to hematopoietic failure in parn-mutant zebrafish with implications for dyskeratosis congenita
Germline mutations in PARN cause dyskeratosis congenita (DC), an inherited bone marrow failure syndrome characterized by multilineage cytopenia and progression to myeloid disease. The mechanisms underlying this malignant transformation have not been fully elucidated. Here we show, using a loss-of-fu...
2026-09-29 | MTBLS15863 | MetaboLights
MetabolomicsA multi-omics study on the metabolic reprogramming of a chlorophyll-deficient, high-protein Auxenochlorella pyrenoidosa mutant (CX41) generated by atmospheric and room temperature plasma (ARTP) mutagenesis.

This project aims to elucidate the molecular mechanism underlying the stable golden-yellow phenotype and enhanced protein accumulation in an Auxenochlorella pyrenoidosa mutant (CX41) generated by ARTP mutagenesis. Through comparative analysis between the wild-type (FACHB-9) and mutant s...

2025-12-26 | MTBLS13574 | MetaboLights
MetabolomicsRuegeria pomeroyi transporter mutant substrate drawdown
Not available
ORGANISM(S): Ruegeria pomeroyi 
ST002381 | MetabolomicsWorkbench
MetabolomicsMetabolomics in Escherichia coli mutant strains
Not available
ORGANISM(S): Escherichia coli 
ST001321 | MetabolomicsWorkbench
MetabolomicsTargeting GSTZ1 sensitizes KRASG12C-mutant lung cancer cells by overcoming glutathione and glycolysis pathway rewiring

KRAS mutations are prevalent in lung cancer, but KRAS G12C inhibitors exhibit limited efficacy, partly due to metabolic adaptations, such as enhanced glutathione metabolism and increased glycolysis. Glutathione S-Transferase Zeta 1 (GSTZ1) is a metabolic enzyme that regulates cell metabolism. How...

2026-05-15 | MTBLS12791 | MetaboLights
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