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ProteomicsProteomics of P granules Z granules and Mutator foci in C.elegans
To examine the protein composition of germ granules subcompartments of C. elegans, while ensuring their physiological integrity, we utilized TurboID-based proximity biotin labeling techniques to idedtify the protein components of P granules, Z granules and Mutator foci in the germline of C.elegans.
ORGANISM(S): Caenorhabditis elegans 
2024-07-14 | PXD046498 | Pride
P granules z granules  mutator foci  proteomics c.elegans 
UnknownMutator Foci Are Regulated by Developmental Stage, RNA, and the Germline Cell Cycle in Caenorhabditis elegans.
Not available
S-EPMC7534428 | biostudies-literature
UnknownDistinct regions of the intrinsically disordered protein MUT-16 mediate assembly of a small RNA amplification complex and promote phase separation of Mutator foci.
Not available
S-EPMC6072111 | biostudies-literature
TranscriptomicsThe DEAD box helicase RDE-12 promotes amplification of RNAi in cytoplasmic foci in C. elegans
RNA interference (RNAi) is a potent mechanism for down-regulating gene expression. Conserved RNAi pathway components are found in animals, plants, fungi and other eukaryotes. In C. elegans, the RNAi response is greatly amplified by the synthesis of abundant secondary siRNAs. Exogenous double strande...
ORGANISM(S): Caenorhabditis elegans 
2014-03-27 | E-GEOD-53830 | biostudies-arrayexpress
TranscriptomicsA Tudor-domain containing protein, SIMR-1, mediates silencing of piRNA target mRNAs by the Mutator Complex
piRNAs play a critical role in the regulation of transposons and other germline genes. In Caenorhabditis elegans, silencing of piRNA target genes is mediated by the Mutator complex, which synthesizes high levels of siRNAs through the activity of an RNA-dependent RNA polymerase. However, how mRNAs re...
ORGANISM(S): Caenorhabditis elegans 
2020-04-27 | GSE138220 | GEO
GenomicsA Tudor-domain containing protein, SIMR-1, mediates silencing of piRNA target mRNAs by the Mutator Complex
A Tudor-domain containing protein, SIMR-1, mediates silencing of piRNA target mRNAs by the Mutator Complex
PRJNA575051 | ENA
GenomicsThe DEAD box helicase RDE-12 promotes amplification of RNAi in cytoplasmic foci in C. elegans
RNA interference (RNAi) is a potent mechanism for down-regulating gene expression. Conserved RNAi pathway components are found in animals, plants, fungi and other eukaryotes. In C. elegans, the RNAi response is greatly amplified by the synthesis of abundant secondary siRNAs. Exogenous double strande...
ORGANISM(S): Caenorhabditis elegans 
2014-03-27 | GSE53830 | GEO
UnknownThe DEAD box helicase RDE-12 promotes amplification of RNAi in cytoplasmic foci in C. elegans.
Not available
S-EPMC4226741 | biostudies-literature
GenomicsCompartmentalized RNA Surveillance Through Membraneless barriers
Biomolecular condensates are thought to compartmentalize biochemical activities, yet how they control macromolecular access without membranes remains unclear. We show that C. elegans germline condensates have distinct RNA selectivity: P granules broadly admit RNA, whereas Mutator foci associate only...
ORGANISM(S): Caenorhabditis elegans 
2025-12-15 | GSE313358 | GEO
GenomicsCaenorhabditis elegans
The DEAD box helicase RDE-12 promotes amplification of RNAi in cytoplasmic foci in C. elegans
PRJNA233484 | ENA
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