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ProteomicsCardiac myofilament isoforms - Identification of cardiac myofilament protein isoforms using multiple mass spectrometry based approaches
Purpose: The identification of protein isoforms in complex biological samples is challenging. We, therefore, used a mass spectrometry (MS) approach to unambiguously identify cardiac myofilament protein isoforms based on the observation of a tryptic peptide consisting of a sequence unique to a partic...
ORGANISM(S): Rattus norvegicus (Rat) 
2014-08-28 | PXD000874 | Pride
Multiple search engines Bioinformatics Cardiomyocyte Sarcomere Protein isoforms Rat cardiac tissue Myofilament proteome Protein sub-isoforms Lc-ms/ms 
UnknownComprehensive assessment of chamber-specific and transmural heterogeneity in myofilament protein phosphorylation by top-down mass spectrometry.
Not available
S-EPMC4637236 | biostudies-literature
TranscriptomicsSlit2 protects hearts against ischemia-reperfusion injury by inhibiting inflammatory responses and maintaining myofilament contractile properties
Background The axon guidance cue Slit2 recently has been found to regulate calcium homeostasis and molecular signaling in various stress events in different organs. However, whether Slit2 plays a role in cardiac ischemia-reperfusion (IR) injury has not been reported. Here, we aimed to investigate th...
ORGANISM(S): Mus musculus 
2019-07-04 | GSE133796 | GEO
ProteomicsCardiomyocyte Contractile Impairment in Heart Failure Results from Reduced BAG3-mediated Sarcomeric Protein Turnover
The association between reduced myofilament force-generating capacity (Fmax) and heart failure (HF) is clear, however the underlying molecular mechanisms are poorly understood. Here, we show impaired Fmax arises from reduced BAG3-mediated sarcomere turnover. Myofilament BAG3 expression decreases in ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) Mus Musculus (ncbitaxon:10090) 
2020-11-06 | MSV000086422 | MassIVE
GenomicsSlit2 protects hearts against ischemia-reperfusion injury by inhibiting inflammatory responses and maintaining myofilament contractile properties
Slit2 protects hearts against ischemia-reperfusion injury by inhibiting inflammatory responses and maintaining myofilament contractile properties
PRJNA552560 | ENA
UnknownTroponin phosphorylation and myofilament Ca2+-sensitivity in heart failure: increased or decreased?
Not available
S-EPMC2610448 | biostudies-literature
ProteomicsHyperphosphorylation of sarcomeric proteins in heart failure with preserved ejection fraction: selective reversal of PKC hyperactivity by cell therapy
Phosphorylation of sarcomeric proteins has been implicated in heart failure with preserved ejection fraction (HFpEF); such changes may contribute to diastolic dysfunction by altering contractility, cardiac stiffness, Ca2+-sensitivity and mechanosensing. Treatment with cardiosphere-derived cells (CDC...
ORGANISM(S): Rattus norvegicus (Rat) 
2022-04-23 | PXD025555 | Pride
Heart failure with preserved ejection fraction (hfpef)  diastolic dysfunction  myofilament phosphorylation Protein kinase c (pkc) Cardiosphere-derived cell (cdc) 
UnknownTop-down proteomics reveals concerted reductions in myofilament and Z-disc protein phosphorylation after acute myocardial infarction.
Not available
S-EPMC4189000 | biostudies-literature
ProteomicsAlteration in Tyrosine Phosphorylation of Cardiac Proteome and EGFR Pathway Contribute to Hypertrophic Cardiomyopathy
Alterations of serine/threonine phosphorylation of the cardiac proteome are a hallmark of heart failure. However, the contribution of tyrosine phosphorylation (pTyr) to the pathogenesis of cardiac hypertrophy remains unclear. We use global mapping to discover and quantify site-specific pTyr in two c...
ORGANISM(S): Mus musculus (Mouse) 
2023-03-10 | PXD036506 | Pride
Heart Tyrosine phosphorylation Proteomics Serine phosphorylation Threonine phosphorylation 
UnknownCardiac contractile dysfunction and protein kinase C-mediated myofilament phosphorylation in disease and aging.
Not available
S-EPMC6719401 | biostudies-literature
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