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ProteomicsCardiomyocyte external mechanical unloading activates modifications of alpha-actinin differently from sarcomere-originated unloading
Loss of myocardial mass in a neonatal rat cardiomyocyte culture is studied to determine whether there is a distinguishable cellular response based on the origin of mechano-signals. The approach herein compares the sarcomeric assembly and disassembly processes in heart cells by imposing mechano-signa...
ORGANISM(S): Rattus Norvegicus (ncbitaxon:10116) 
2023-01-05 | MSV000091010 | MassIVE
GenomicsGenome-wide maps of Sin3A and Sin3B binding in C2C12 myoblasts and differentiated myotubes
Sin3A and Sin3B bind to distinct and overlapping target sites. Sin3 proteins bind to distinct sites in cycling myoblasts whereas there is a converge of Sin3A and Sin3B proteins to sites in differentiated myotubes. We identified a subset of Sin3 target genes involved in muscle differentiation and phy...
ORGANISM(S): Mus musculus 
2011-01-01 | E-GEOD-22554 | biostudies-arrayexpress
ProteomicsSeptin 7 Interacts With Numb To Preserve Sarcomere Structural Organization And Muscle Contractile Function
Here, we investigated mechanisms by which aging-related reductions of the levels of Numb in skeletal muscle fibers contribute to loss of muscle strength and power, two critical features of sarcopenia. Numb is an adaptor protein best known for its critical roles in development including asymmetric ce...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2022-04-28 | MSV000089327 | MassIVE
ProteomicsRibosomal Protein SA (RPSA) is required for localized translation and sarcomere maintenance
Cardiomyocyte sarcomeres contain localized ribosomes, but the factors responsible for their localization and the significance of localized translation are unknown. Using proximity labeling, we identified Ribosomal Protein SA (RPSA) as a Z-line protein. In cultured cardiomyocytes, the loss of RPSA le...
ORGANISM(S): Rattus norvegicus (Rat) 
2024-06-04 | PXD046385 | Pride
Ribosome Localized translation Proximity labeling Sarcomere Z-line 
TranscriptomicsEffect of 5-azacytidine on gene expression in C2C12 myoblasts
Mesenchymal progenitor cells can be differentiated in vitro into myotubes that exhibit many characteristic features of primary mammalian skeletal muscle fibers. However, in general, they do not show the functional excitation-contraction coupling or the striated sarcomere arrangement typical of matur...
ORGANISM(S): Mus musculus 
2012-01-01 | E-GEOD-30192 | biostudies-arrayexpress
GenomicsYAP Promotes Microtubule Growth to Facilitate Sarcomere Disassembly in Adult Cardiomyocytes
YAP Promotes Microtubule Growth to Facilitate Sarcomere Disassembly in Adult Cardiomyocytes
PRJNA1449551 | ENA
GenomicsCHD4 and the NuRD complex directly control cardiac sarcomere formation
CHD4 and the NuRD complex directly control cardiac sarcomere formation
PRJNA429439 | ENA
GenomicsLoss of Hectd1 disrupts muscle sarcomere assembly and causes combined desmin-nemaline myopathy
Loss of Hectd1 disrupts muscle sarcomere assembly and causes combined desmin-nemaline myopathy
PRJNA1138709 | ENA
GenomicsHomo sapiens
Sarcomere Genes
PRJNA1048307 | ENA
UnknownIn vivo Sarcomere Lengths and Sarcomere Elongations Are Not Uniform across an Intact Muscle.
Not available
S-EPMC4879144 | biostudies-literature
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