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MetabolomicsLipin1 deficiency causes sarcoplasmic reticulum stress and chaperone-responsive myopathy
As a consequence of impaired glucose or fatty acid metabolism, bioenergetic stress in skeletal muscles may trigger myopathy and rhabdomyolysis. Genetic mutations causing loss of function of the LPIN1 gene frequently lead to severe rhabdomyolysis bouts in children, though the metabolic alterations an...
2019-01-07 | MTBLS750 | MetaboLights
MetabolomicsMetabolomic signatures discriminate horses with clinical signs of atypical myopathy from healthy co-grazing horses
Atypical myopathy (AM) is a severe rhabdomyolysis syndrome that occurs in grazing horses. Despite the presence of toxins in their blood, all horses from the same pasture are not prone to display clinical signs of AM. The objective of this study was to compare the blood metabolomic profiles of horses...
2021-08-31 | MTBLS2579 | MetaboLights
MetabolomicsMetabolic signature of idiopathic inflammatory myopathy
Not available
ORGANISM(S): Homo sapiens 
ST002196 | MetabolomicsWorkbench
GenomicGenetic Susceptibility to Statin-Induced Myopathy

Severe myopathic events occur in 0.1-0.5% of patients taking statins. Although genetic association studies have identified some possibly associated gene loci, these have not been reproducible in additional studies with independent patient cohorts. A more reasonable explanation for susceptibility ...

phs001342 | dbGaP
TranscriptomicsTranscription profiling of different types of skeletal muscles from wild type and alpha tropomyosin transgenic slow mice to investigate the molecular mechanisms implicated in the mouse model of nemaline myopathy.
The aim of this study was to investigate the molecular mechanisms implicated in this mouse model of nemaline myopathy, and to further compare the molecular disease response in different skeletal muscles. For this purpose, snap frozen skeletla muscle specimens from wild type and transgenic for alpha ...
ORGANISM(S): Mus musculus 
2007-12-01 | E-GEOD-3384 | biostudies-arrayexpress
TranscriptomicsGene expression profiling in equine polysaccharide storage myopathy
Standardized muscular biopsies of the dorsal compartment of the gluteus medius muscle were performed in 7 horses suffering from equine polysaccharide storage myopathy (PSSM) and 6 sound Norman Cob horses . Gene expression analysis was performed using an equine oligonucleotide microarray which includ...
ORGANISM(S): Equus caballus 
2009-04-08 | E-GEOD-15572 | biostudies-arrayexpress
TranscriptomicsInducible expression of PrPC in mouse skeletal muscles results in myopathy characterized by changes in gene expression
Over-expression of wild type PrP in skeletal muscles is sufficient to cause a primary myopathy with no signs of peripheral neuropathy, possibly due to accumulation of a cytotoxic truncated form of PrP and/or PrP aggregation. In this study we used DNA microarrays to identify 1499 transcripts that ar...
ORGANISM(S): Mus musculus 
2008-08-27 | E-GEOD-12576 | biostudies-arrayexpress
TranscriptomicsInflammation-induced acute phase response in skeletal muscle and critical illness myopathy
Objectives: Systemic inflammation is a major risk factor for critical-illness myopathy (CIM) but its pathogenic role in muscle is uncertain. We observed that interleukin 6 (IL-6) and serum amyloid A1 (SAA1) expression was upregulated in muscle of critically ill patients. To test the relevance of the...
ORGANISM(S): Homo sapiens 
2014-05-06 | E-GEOD-53702 | biostudies-arrayexpress
ProteomicsSarikaya_HistoryMyopathy_P124_6600
This dataset consists of 6 raw MS files, acquired on AB Sciex TripleTOF 6600 mass spectrometer operated in Data Dependent Acquisition mode. Samples were generated by Ege Sarikaya. Sample processing was performed by Ege Sarikaya and Cassandra Wong. Mass spectrometry acquisition and data analysis was...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2022-07-07 | MSV000089845 | MassIVE
ProteomicsSarikaya_HistoryMyopathy_P124_OrbiElite
This dataset consists of 4 raw MS files, acquired on Orbitrap Elite mass spectrometer operated in Data Dependent Acquisition mode. Samples were generated by Ege Sarikaya. Sample processing was performed by Ege Sarikaya and Cassandra Wong. Mass spectrometry acquisition and data analysis was performe...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2022-07-07 | MSV000089844 | MassIVE
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