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ProteomicsIP-MS identification of protein interaction for Na (+), K (+)-ATPase beta1 subunit
This project aims to identify proteins that may interact with the sodium potassium pump (ATPase) beta1 subunit in the human lung.
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2020-02-02 | MSV000084881 | MassIVE
TranscriptomicsMicroarray analyses of microRNA expressions in comparison with immortal healthy mammary epithelial cells, breast cancer cells, and long-term-cultured breast cancer stem cells
RNA extraction and microarray analysis total RNA from immortalized normal mammary epithelial cells (184A1, MCF-12A), breast cancer cells (MDA-MB-231, MCF-7, MDA-MB-468, SK-BR-3), BCSC (MDA-MB-231SC, MCF-7SC, XM322, XM607). MDA-MB-231SC and MCF-7SC originating from breast cancer cell lines; XM322 and...
ORGANISM(S): Homo sapiens 
2017-12-01 | E-MTAB-5584 | biostudies-arrayexpress
TranscriptomicsMicroRNA profiling of human hepatocellular carcinoma samples shows miR-221 overexpression contributes to liver tumorigenesis
We profiled miRNA expression in tissue samples (104 HCC, 90 adjacent cirrhotic livers, 21 normal livers) as well as in 35 HCC cell lines. A set of 12 miRNAs (including miR-21, miR-221/222, miR-34a, miR-519a, miR-93,miR-96, and let-7c) was linked to disease progression from normal liver through cirrh...
ORGANISM(S): Homo sapiens 
2009-12-08 | E-TABM-866 | biostudies-arrayexpress
TranscriptomicsConnecting microRNA genes to the core transcriptional regulatory circuitry of embryonic stem cells
MicroRNAs (miRNAs) are crucial for normal embryonic stem (ES) cell self-renewal and cellular differentiation, but how miRNA gene expression is controlled by the key transcriptional regulators of ES cells has not been established. We describe here a new map of the transcriptional regulatory circuitr...
ORGANISM(S): Mus musculus 
2008-07-29 | E-GEOD-11724 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human 13q14-\- cell line expressing doxycylin-inducible miR-15a/16-1 and empty vector (EV)
Reexpression of microRNAs miR-15a/16-1 in a cell line deficient for these miRs (homozygous deletion of chromosomal region 13q14) results in the downregulation of certain mRNAs. Experiment Overall Design: A doxycyclin-inducible expression vector containing miR-15a/16-1 was transfected into CLL-I83E95...
ORGANISM(S): Homo sapiens 
2009-12-05 | E-GEOD-18866 | biostudies-arrayexpress
TranscriptomicsmiR-126 Orchestrates an Oncogenic Program in B-Cell Precursor Acute Lymphoblastic Leukemia
MicroRNA (miRNA)-126 is a known regulator of hematopoietic stem cell quiescence. We engineered murine hematopoiesis to express miRNA-126 across all differentiation stages. Thirty percent of mice developed monoclonal B cell leukemia, which was prevented or regressed when a tetracycline-repressible mi...
ORGANISM(S): Homo sapiens 
2016-06-14 | E-GEOD-78078 | biostudies-arrayexpress
TranscriptomicsmiR-21 OVA Lung
Lungs from miR-21+/+ and miR-21-/- mice sensitized with OVA/Alum and challenged with either saline or OVA.
ORGANISM(S): Mus musculus 
2011-08-25 | E-MEXP-3119 | biostudies-arrayexpress
TranscriptomicsRNA-seq analysis of withdrawal of miR-155 hyperexpression in miR-155-addicted tumors
Overexpression of miR-155 in hematological tissue leads to the onset of lymphoma, and Tet-off shutdown of this overexpression reverses the disease phenotype in mir-155LSLtTA mice. This study compares the gene expression profiles of tumors with miR-155 overexpression and withdrawal. Examination of mR...
ORGANISM(S): Mus musculus 
2015-01-30 | E-GEOD-61851 | biostudies-arrayexpress
TranscriptomicsmiRNA profiling of sarcoidosis Treg cells
Sarcoidosis is characterized by exaggerated immune response to unknown agent and can affect different organs. One of the main players in the pathology of the disease are regulatory T cells (Tregs), however up to date there are no insides on the possible molecular alterations of this particular cell ...
ORGANISM(S): Homo sapiens 
2018-09-29 | E-MTAB-6590 | biostudies-arrayexpress
TranscriptomicsGene expression of SUM159-mir100 ALDH+ and ALDH- cells from CTRL or mir100-overexpressing group
Emerging evidence suggest that miRNAs play an essential role in self-renewal and differentiation of normal and malignant stem cells by regulating the expression of key stem cell regulatory genes. Here we demonstrate that mir-100 expression is related to cellular differentiation state with lowest exp...
ORGANISM(S): Homo sapiens 
2014-12-04 | E-GEOD-59361 | biostudies-arrayexpress
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