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MetabolomicsProtein-metabolite interactomics of carbohydrate metabolism reveal regulation of lactate dehydrogenase

Metabolic networks are interconnected and influence diverse cellular processes. The protein-metabolite interactions that mediate these networks are frequently low affinity and challenging to systematically discover. We developed mass spectrometry integrated with equilibrium dialysis for the disco...

2023-08-07 | MTBLS7237 | MetaboLights
MetabolomicsRedirected nuclear glutamate dehydrogenase supplies Tet3 with α-ketoglutarate in neurons

Tet3 is the main α-ketoglutarate (αKG)-dependent dioxygenase in neurons that converts 5-methyl-dC into 5-hydroxymethyl-dC and further on to 5-formyl- and 5-carboxy-dC. Neurons possess high levels of 5-hydroxymethyl-dC that further increase during neural activity to establish transcriptional plast...

2021-06-24 | MTBLS2852 | MetaboLights
MetabolomicsSelective galactose culture condition reveals distinct metabolic signatures in pyruvate dehydrogenase and complex I deficient human skin fibroblasts

INTRODUCTION: A decline in mitochondrial function represents a key factor of a large number of inborn errors of metabolism, which lead to an extremely heterogeneous group of disorders.

OBJECTIVES: To gain insight into the biochemical consequences of mitocho...

2021-10-06 | MTBLS761 | MetaboLights
ProteomicsCharacterization of ND5 subunit of bovine mitochondrial NADH-ubiquinone oxidoreductase (complex I)
This project contains MALDI-TOF/TOF spectra derived from the ND5 subunit of bovine mitochondrial NADH-ubiquinone oxidoreductase (complex I).
ORGANISM(S): Bos Taurus 
2022-07-29 | PXD031179 | JPOST Repository
MetabolomicsIsocitrate dehydrogenase-1/Glioma Fluxomics Study
Not available
ORGANISM(S): Homo sapiens 
ST000302 | MetabolomicsWorkbench
TranscriptomicsTranscriptomic analysis of lactate dehydrogenase negative mutant of Enterococcus faecalis V583
In order to study the effect of lactate dehydrogenase (?ldh 1.2) mutant on the transcriptome DNA microarray technology was used. Stains were grown in a chemically defined medium (CDM-LAB) containing 1.1% of glucose as a carbon sources at 37?C on anaerobic condition to an optical density of 0.6.
ORGANISM(S): Enteroccus faecalis V583 
2010-12-13 | E-MTAB-472 | biostudies-arrayexpress
TranscriptomicsSteroid Receptor Coactivator 1 is an Integrator of Glucose and NAD(+)/NADH Homeostasis
SRC-1 affects the expression of complex I of the mitochondrial electron transport chain, a set of enzymes responsible for the conversion of NADH to NAD(+). NAD(+) and NADH were subsequently identified as metabolites that underlie SRC-1's response to glucose deprivation. Knockdown of SRC-1 in glycoly...
ORGANISM(S): Homo sapiens 
2014-04-16 | E-GEOD-56843 | biostudies-arrayexpress
ProteomicsThe metabolic response of Pseudomonas taiwanensis to NADH dehydrogenase deficiency
We investigated the essentiality of the three NADH dehydrogenases of the respiratory chain of the obligate aerobe Pseudomonas taiwanensis VLB120 and the impact of the knockouts of corresponding genes on its physiology and metabolism.
ORGANISM(S): Pseudomonas taiwanensis 
2020-04-08 | PXD013623 | Pride
Pseudomonas  nadh dehydrogenase  respiratory activity  oxidative stress  electron transport chain 
ProteomicsCysteine oxidation as a regulatory mechanism of Arabidopsis plastidial NAD-dependent malate dehydrogenase
Malate dehydrogenases (MDHs) catalyze a reversible NAD(P)-dependent-oxidoreductase reaction that plays an important role in central metabolism and redox homeostasis of plant cells. Recent studies suggest a moonlighting function of plastidial NAD-dependent MDH (plNAD-MDH) in plastid biogenesis, indep...
ORGANISM(S): Escherichia Coli 
2024-04-29 | PXD048384 | JPOST Repository
Genomics
Naphthaquinone-NADH dehydrogenase pairing
PRJNA1294558 | ENA
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