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Transient let-7/miR-98 reprograms primed pluripotency to induce naive human PSCs
Feeder-free culture of naive human PSCs preserving embryonic, extraembryonic and blastoid potential
Studies of the catalytically inactive DNA methyltransferase Dnmt3l have mainly been limited to mice where Dnmt3l was shown to be essential for fertility, de novo DNA methylation in early embryos and maintenance of DNA methylation patterns in mouse pluripotent stem cells. In humans, recent work revea...
ORGANISM(S): Homo sapiens (Human) 
2026-08-31 | PXD053638 | Pride
Feeder-free culture of naive human PSCs preserving embryonic, extraembryonic and blastoid potential
Naive human pluripotent stem cells (hPSCs) represent a pre-implantation epiblast state able to efficiently differentiate into embryonic and extraembryonic pre-implantation lineages and to self-organise into blastocyst-like structures called blastoids. Naive hPSCs maintenance commonly relies on mouse...
ORGANISM(S): Bos taurus (Bovine) Rattus norvegicus (Rat) 
2025-12-22 | PXD059820 | Pride
Naive human pluripotent stem cells (hPSCs) represent a pre-implantation epiblast state able to efficiently differentiate into embryonic and extraembryonic pre-implantation lineages and to self-organise into blastocyst-like structures called blastoids. Naive hPSCs maintenance commonly relies on mouse...
ORGANISM(S): Mus musculus (Mouse) 
2025-12-22 | PXD072053 | Pride
Feeder-free culture of naive human PSCs preserving embryonic, extraembryonic and blastoid potential
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