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ProteomicsIdentification of the acetylated lysine residues of Dnmt3L protein in murine embryonic stem cells
The core purpose of this project is to identify the novel epigenetic factors which play a crucial role on regulating stem cells developed from embryo development to ageing through the longitudinal analysis of their transcriptome, protein interactome, and post- translational modification network. Thu...
ORGANISM(S): Mus musculus (Mouse) 
2025-05-26 | PXD032953 | Pride
Dna methyltransferases (dnmts) Embryonic stem cell (esc) Gel-lc-ms/ms Mus musculus (mouse) Proteome Acetylation 
TranscriptomicsDNMT3L promotes quiescence in postnatal spermatogonial progenitor cells
We analyzed transcriptome profiles of postnatal germ cells and demonstrated that DNMT3L is important for spermatogonial stem/progenitor cell development Examination of wild-type and Dnmt3l knockout smaples in postnatal male germ cells
ORGANISM(S): Mus musculus 
2014-07-03 | E-GEOD-54411 | biostudies-arrayexpress
TranscriptomicsDnmt3l-knockout donor cells improve somatic cell nuclear transfer reprogramming efficiency
We found that Dnmt3l-KO donor cells display decreased levels of H3K9me3 and H3K27me3 accumulation, higher level of active histone mark H3K27ac and increased cytoplasmic localization of HDAC1, implicating a permissive epigenetic state beneficial for nuclear reprogramming. To investigate the gene expr...
ORGANISM(S): Mus musculus 
2015-08-01 | E-GEOD-69007 | biostudies-arrayexpress
ProteomicsDNMT3L safeguards the epigenome and developmental potential of naive human pluripotent stem cells and blastoids
Studies of the catalytically inactive DNA methyltransferase Dnmt3l have mainly been limited to mice where Dnmt3l was shown to be essential for fertility, de novo DNA methylation in early embryos and maintenance of DNA methylation patterns in mouse pluripotent stem cells. In humans, recent work revea...
ORGANISM(S): Homo sapiens (Human) 
2026-08-31 | PXD053638 | Pride
Dnmt3l  naive pscs  blastoids  histones  ptms  protein interactions 
ProteomicsDNMT3L safeguards the epigenome and developmental potential of naive human pluripotent stem cells and blastoids
DNA methylation is essential for mammalian development. Studies of the catalytically inactive DNA methyltransferase Dnmt3l have mainly been limited to mice where Dnmt3l was shown to be essential for fertility, de novo DNA methylation in early embryos and maintenance of DNA methylation patterns in mo...
ORGANISM(S): Homo sapiens (Human) 
2026-08-25 | PXD055233 | Pride
Keywords: dnmt3l  human naïve escs  dna methylation  hptms  blastoids  epigenestis 
GenomicsDNA methylation changes in Dnmt3L-deficient mouse embryonic stem cells (mESCs)
DNA methylation changes in Dnmt3L-deficient mouse embryonic stem cells (mESCs)
PRJNA478833 | ENA
GenomicsTransient DNMT3L expression in mouse embryonic fibroblast (MEFs)
Transient DNMT3L expression in mouse embryonic fibroblast (MEFs)
PRJNA558078 | ENA
GenomicsEpigenome analysis of normal and DNMT3L-overexpressing human neurons [array]
Epigenome analysis of normal and DNMT3L-overexpressing human neurons [array]
PRJNA660026 | ENA
GenomicsDNMT3L crosstalk with piRNA biogenesis in postnatal spermatogonial progenitor cells
DNMT3L crosstalk with piRNA biogenesis in postnatal spermatogonial progenitor cells
PRJNA1380485 | ENA
GenomicsDNMT3L is crucial for the osteogenesis ability of mesenchymal stem cells
DNMT3L is crucial for the osteogenesis ability of mesenchymal stem cells
PRJNA454223 | ENA
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