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TranscriptomicsEffect of NDRG3 overexpression on cell response to hypoxia
Analysis of HeLa cells overexpressing NDRG3 or exposed to hypoxic condition. Gene expression profiles of HeLa cells stably expressing NDRG3 were compared to gene expression profiles of HeLa stable cells expressing mock or hypoxia-mediated gene expression profiles.
ORGANISM(S): Homo sapiens 
2015-07-24 | E-GEOD-55211 | biostudies-arrayexpress
TranscriptomicsEffect of NDRG3 or HIF-1α knockdown on cell response to hypoxia
Analysis of Huh-7 hepatocarcinoma cell line depleted of NDRG3 or HIF-1α under hypoxic condition. HIF-1α and NDRG3 have distinct functions in hypoxia responses. Results provide insight into molecular basis of HIF-independent signaling in the development and progression of hypoxic tumors Gene expressi...
ORGANISM(S): Homo sapiens 
2015-07-24 | E-GEOD-55212 | biostudies-arrayexpress
ProteomicsAnti-proteolytic regulation of KRAS by USP9X/NDRG3 in KRAS-driven cancer development
Cancers with activating mutations of KRAS show a high prevalence and poor prognosis but remain intractable, requiring innovative strategies to overcome the poor targetability of KRAS. Here, we report that KRAS expression was post-translationally up-regulated through the deubiquitination of KRAS prot...
ORGANISM(S): Homo sapiens (Human) 
2025-05-07 | PXD052379 | Pride
Kras protein deubiquitination  ndrg3  usp9x  pancreatic cancer 
TranscriptomicsEffect of NDRG3 expression on cell response to hypoxia
Analysis of Huh-7 hepatocarcinoma cell line depleted of NDRG3 or HIF-1α under hypoxic condition. HIF-1α and NDRG3 have distinct functions in hypoxia responses. Results provide insight into molecular basis of HIF-independent signaling in the development and progression of hypoxic tumors Gene expressi...
ORGANISM(S): Homo sapiens 
2015-07-24 | E-GEOD-59729 | biostudies-arrayexpress
ProteomicsAnti-proteolytic regulation of KRAS by USP9X/NDRG3 in KRAS-driven cancer development
Cancers with activating mutations of KRAS show a high prevalence and poor prognosis but remain intractable, requiring innovative strategies to overcome the poor targetability of KRAS. Here, we report that KRAS expression was post-translationally up-regulated through the deubiquitination of KRAS prot...
ORGANISM(S): Homo sapiens (Human) 
2025-05-06 | PXD051954 | Pride
Kras protein deubiquitination  ndrg3  usp9x  pancreatic cancer 
TranscriptomicsEffect of NDRG3 over-expression and knockdown on cell response to hypoxia
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Homo sapiens 
2015-07-24 | E-GEOD-55214 | biostudies-arrayexpress
GenomicsRNA-sequencing of control (GFP) or NDRG3-depleted pancreatic cancer cell lines
RNA-sequencing of control (GFP) or NDRG3-depleted pancreatic cancer cell lines
PRJNA781842 | ENA
GenomicsEffect of Ndrg3-deficiency on gene expression by CD8SP thymocytes
Effect of Ndrg3-deficiency on gene expression by CD8SP thymocytes
PRJNA1145348 | ENA
TranscriptomicsRNA-sequencing of control (GFP) or NDRG3-depleted pancreatic cancer cell lines
We perfomed RNA-sequencing for searching upstream regulators regulated by NDRG3 gene. RNA profiles of each cell line were used to figure out Differentially Expressed Genes (DEG) by NDRG3 depletion, we found NDRG3-related upstream regulators by applicating DEG to Ingenuity Pathway Analysis (IPA).
ORGANISM(S): Homo sapiens 
2022-08-31 | GSE189171 | GEO
TranscriptomicsEffect of NDRG3 expression on cell response to hypoxia
Analysis of Huh-7 hepatocarcinoma cell line depleted of NDRG3 or HIF-1α under hypoxic condition. HIF-1α and NDRG3 have distinct functions in hypoxia responses. Results provide insight into molecular basis of HIF-independent signaling in the development and progression of hypoxic tumors
ORGANISM(S): Homo sapiens 
2015-07-24 | GSE59729 | GEO
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