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TranscriptomicsA chemical genetic approach identifies piperazine antipsychotics as promoters of CNS neurite growth on inhibitory substrates.
Injury to the central nervous system (CNS) may result in lifelong loss of function due, in part, to the regenerative failure of CNS neurons. Major barriers to regeneration faced by injured CNS neurons include inhibitory proteins derived from myelin and the astroglial scar. Previously, we described...
ORGANISM(S): Homo sapiens 
2012-04-29 | E-GEOD-34331 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse neurite outgrowth and regeneration (super series)
This SuperSeries is composed of the following subset Series:; GSE9738: Analysis of gene expression during neurite outgrowth and regeneration (430A and 420A 2.0 array); GSE9739: Analysis of gene expression during neurite outgrowth and regeneration (MG-U74A); GSE9740: Analysis of gene expression durin...
ORGANISM(S): Mus musculus 
2008-04-10 | E-GEOD-9744 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse neurite outgrowth and regeneration
We have undertaken a genome-wide study of transcriptional activity in embryonic superior cervical ganglia (SCG) and dorsal root ganglia (DRG) during a time course of neurite outgrowth in vitro. Gene expression observed in these models likely includes both developmental gene expression patterns and ...
ORGANISM(S): Mus musculus 
2008-06-16 | E-GEOD-9738 | biostudies-arrayexpress
ProteomicsSoluble SORLA enhances neurite outgrowth and regeneration through activation of EGFR and MAPK pathways
SORLA is a type I transmembrane component associated with Alzheimers disease (AD) risk. Although SORLA is abundantly expressed in neurons, physiological roles for SORLA remain yet unclear. Here, we show that cultured neurons overexpressing SORLA (SORLA TG) feature enhanced neurite length, and accele...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2020-05-12 | MSV000085400 | MassIVE
TranscriptomicsTranscription profiling of mouse embryonic superior cervical ganglia (SCG) and dorsal root ganglia (DRG) during a time series of neurite outgrowth in vitro
We have undertaken a genome-wide study of transcriptional activity in embryonic superior cervical ganglia (SCG) and dorsal root ganglia (DRG) during a time course of neurite outgrowth in vitro. Gene expression observed in these models likely includes both developmental gene expression patterns and ...
ORGANISM(S): Mus musculus 
2008-06-16 | E-GEOD-9739 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse embryonic superior cervical ganglia (SCG) and dorsal root ganglia (DRG) during a time series of neurite outgrowth in vitro
We have undertaken a genome-wide study of transcriptional activity in embryonic superior cervical ganglia (SCG) and dorsal root ganglia (DRG) during a time course of neurite outgrowth in vitro. Gene expression observed in these models likely includes both developmental gene expression patterns and ...
ORGANISM(S): Mus musculus 
2008-06-16 | E-GEOD-9740 | biostudies-arrayexpress
TranscriptomicsThe flavonoid glycoside isoquercitrin promotes neurite network formation through a down regulation of RhoA activity
We observed extensive neurite formation in NG108-15 cells cultured in the presence of the flavonoid, isoquercitrin. To help determine the mechanism of neuritogenesis, microarray analysis was performed on samples treated with 40 uM isoquercitrin for 24 hrs.
ORGANISM(S): Mus musculus 
2012-10-19 | E-MEXP-3418 | biostudies-arrayexpress
ProteomicsProteomics analysis of proteins co-immunoprecipitated with MIDN-Flag in PC-12 cells
We have previously identified midnolin (MIDN) as a genetic risk factor for Parkinson's disease. However, the molecular entity of MIDN that regulates neuronal phenotypes remains unclear. To investigate the molecular function of MIDN, we examined proteins associated with MIDN in PC-12 cells. We perfor...
ORGANISM(S): Rattus Rattus (black Rat) 
2024-09-13 | PXD053265 | JPOST Repository
TranscriptomicsTotal RNAseq of sfpq sibling (+/+, +/-) and null (-/-) primary zebrafish neuron cellular and neurite tissue
Zebrafish primary neurons either sfpq sibling/control (+/+, +/-) or null (-/-) were cultured in transwell inserts. At DIV2, for each genotype, cellular and neurite tissues were separately isolated, RNA extracted and total RNAseq performed.
ORGANISM(S): Danio rerio 
2022-02-19 | E-MTAB-11431 | biostudies-arrayexpress
GenomicsEnhancing Retinal Photoreceptor Neurite Outgrowth with Small Molecules and Growth Factors
Enhancing Retinal Photoreceptor Neurite Outgrowth with Small Molecules and Growth Factors
PRJNA1157205 | ENA
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