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TranscriptomicsHDAC inhibitors attenuate the development of hypersensitivity in models of neuropathic pain [DRG tissue]
Histone deacetylase inhibitors (HDACIs) interfere with the epigenetic process of histone acetylation and are known to have analgesic properties in models of chronic inflammatory pain. The aim of this study was to determine whether these compounds could also affect neuropathic pain. Different class I...
ORGANISM(S): Rattus norvegicus 
2013-10-01 | E-GEOD-51295 | biostudies-arrayexpress
TranscriptomicsHDAC inhibitors attenuate the development of hypersensitivity in models of neuropathic pain [spinal cord tissue]
Histone deacetylase inhibitors (HDACIs) interfere with the epigenetic process of histone acetylation and are known to have analgesic properties in models of chronic inflammatory pain. The aim of this study was to determine whether these compounds could also affect neuropathic pain. Different class I...
ORGANISM(S): Rattus norvegicus 
2013-10-01 | E-GEOD-51294 | biostudies-arrayexpress
TranscriptomicsRNA-seq of rat dorsal root ganglia after ligation to investigate central nervous system transcriptomics in chronic pain using agnostic splice site discovery methods
The study pursued dual goals: To advance mRNA-seq bioinformatics towards unbiased transcriptome capture and to demonstrate its potential for discovery in neuroscience by applying the approach to an in vivo model of neurological disease. We found that 12.4% of known genes were induced and 7% were sup...
ORGANISM(S): Rattus norvegicus 
2010-05-01 | E-GEOD-20895 | biostudies-arrayexpress
TranscriptomicsMicroarray analyses of mouse dorsal root ganglia tissue for six different pain models
Six different mouse pain models were studied: (1) tumour-injection model for bone cancer pain; (2) partial sciatic nerve ligation (PSL) for neuropathic pain; (3) mechanical joint loading for osteoarthritis pain; (4) oxaliplatin-induced painful neuropathy for chemotherapy-induced pain; (5) hyperalges...
ORGANISM(S): Mus musculus 
2018-06-11 | E-MTAB-6864 | biostudies-arrayexpress
TranscriptomicsRGS9-2-controlled adaptations in the striatum determine the onset of action and eficacy of antidepressants in neuropathic pain states
The striatal protein Regulator of G protein signaling-2 (RGS9-2) plays a key modulatory role in opioid, monoamine and other GPCR responses. Here, we use the murine spared-nerve injury model of neuropathic pain to investigate the mechanism by which RGS9-2 in the nucleus accumbens (NAc), a brain regio...
ORGANISM(S): Mus musculus 
2015-08-25 | E-GEOD-71527 | biostudies-arrayexpress
TranscriptomicsGenome-wide analysis of dorsal root ganglion (DRG) gene expression after morphine or oxycodone treatment
Analyse of gene expression modification after chronic analgesic treatment. The hypothesis tested in the present study was that oxycodone and morphine induced gene expression modification. Results provide important information to understand the analgesic effects of oxycodone as compared to morphine i...
ORGANISM(S): Rattus norvegicus 
2014-01-09 | E-GEOD-53897 | biostudies-arrayexpress
GenomicsGCN2 regulates paclitaxel-induced neuropathic pain
GCN2 regulates paclitaxel-induced neuropathic pain
PRJNA1235301 | ENA
ProteomicsRecombinant dimeric PICK1 protein inhibitors for long-term relief of chronic pain by AAV therapeutics
Chronic neuropathic pain’s impact, persistence, and limited treatments render it relevant for gene therapy. Here, we describe the development and application of self-assembling dimeric peptide inhibitors of the pain-associated scaffolding protein PICK1 (protein interacting with C-kinase 1) delivered...
ORGANISM(S): Mus musculus (Mouse) 
2026-04-10 | PXD074049 | Pride
Pick1  protein interacting with c-kinase 1  neuropathic pain Pain treatment  neuropathic pain treatment  gene therapy  aav therapeutics. 
ProteomicsRecombinant dimeric PICK1 protein inhibitors for long-term relief of chronic pain by AAV therapeutics
Chronic neuropathic pain’s impact, persistence, and limited treatments render it relevant for gene therapy. Here, we describe the development and application of self-assembling dimeric peptide inhibitors of the pain-associated scaffolding protein PICK1 (protein interacting with C-kinase 1) delivered...
ORGANISM(S): Mus musculus (Mouse) 
2026-04-10 | PXD073925 | Pride
Pick1  protein interacting with c-kinase 1  neuropathic pain Pain treatment  neuropathic pain treatment  gene therapy  aav therapeutics 
TranscriptomicsTNT model of neuropathic pain
In this experiment we compare the effect of tibial nerve transection on gene expression within the dorsal root ganglion (DRG) of rats.
ORGANISM(S): Rattus norvegicus 
2014-08-01 | E-MTAB-2260 | biostudies-arrayexpress
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