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GenomicsNVP-BHG712 alleviates ovariectomy-induced osteoporosis by modulating osteoclastogenesis
NVP-BHG712 alleviates ovariectomy-induced osteoporosis by modulating osteoclastogenesis
PRJNA1086539 | ENA
TranscriptomicsNVP-BHG712 alleviates ovariectomy-induced osteoporosis by modulating osteoclastogenesis
To investigate the effect of NVP-BHG712 on osteoclast differentiation, BMMs were removed from femorae of C57BL/6 mice and treated with NVP-BHG712 for RNA-seq
ORGANISM(S): Mus musculus 
2024-12-01 | GSE261350 | GEO
ProteomicsSite-Specific Competitive Kinase Inhibitor Target Profiling Using Phosphonate Affinity Tags
Protein kinases are prime targets for drug development due to their involvement in various cancers. However, selective inhibition of kinases, while avoiding off-target effects remains a significant challenge for the development of protein kinase inhibitors. Activity-based protein profiling (ABPP), i...
ORGANISM(S): Homo sapiens (Human) 
2025-05-07 | PXD058749 | Pride
Chemical proteomics  activity-based protein profiling  site-specific  protein kinase inhibitor profiling  ephrin receptor inhibitor  nvp-bhg712 
UnknownOptimization of the Lead Compound NVP-BHG712 as a Colorectal Cancer Inhibitor.
Not available
S-EPMC10133194 | biostudies-literature
UnknownThe Pyrazolo[3,4-d]pyrimidine-Based Kinase Inhibitor NVP-BHG712: Effects of Regioisomers on Tumor Growth, Perfusion, and Hypoxia in EphB4-Positive A375 Melanoma Xenografts.
Not available
S-EPMC7662635 | biostudies-literature
ProteomicsSingle methyl group positioning opens new chemical space for EPH receptor kinase inhibition
EPHrin receptors (EPH) are transmembrane receptor tyrosine kinases. Their extracellular domains bind specifically to ephrin A/B ligands, and this binding modulates the intracellular kinase activity. EPHs are key players in bidirectional intercellular signalling, controlling cell morphology, adhesion...
ORGANISM(S): Homo sapiens (Human) 
2018-09-05 | PXD009188 | Pride
Eph receptor Selectivity profiling Kinase inhibitor Kinobeads 
TranscriptomicsIdentification of Ephrin type-B receptor 4 (EphB4) as a critical mediator of tissue fibrosis [snRNA-seq]
Pulmonary fibrosis (PF) is a pathology associated with interstitial lung diseases (ILDs), including idiopathic pulmonary fibrosis (IPF). Fibrosis promotes continual secretion of extracellular matrix (ECM), producing non-functional scar tissue and causing organ failure. This study investigated the ty...
ORGANISM(S): Mus musculus 
2025-09-25 | GSE273467 | GEO
TranscriptomicsIdentification of Ephrin type-B receptor 4 (EphB4) as a critical mediator of tissue fibrosis [RNA-seq]
Pulmonary fibrosis (PF) is a pathology associated with interstitial lung diseases (ILDs), including idiopathic pulmonary fibrosis (IPF). Fibrosis promotes continual secretion of extracellular matrix (ECM), producing non-functional scar tissue and causing organ failure. This study investigated the ty...
ORGANISM(S): Homo sapiens 
2025-09-25 | GSE205613 | GEO
TranscriptomicsIdentification of Ephrin type-B receptor 4 (EphB4) as a critical mediator of tissue fibrosis [RNA-seq]
Pulmonary fibrosis (PF) is a pathology associated with interstitial lung diseases (ILDs), including idiopathic pulmonary fibrosis (IPF). Fibrosis promotes continual secretion of extracellular matrix (ECM), producing non-functional scar tissue and causing organ failure. This study investigated the ty...
ORGANISM(S): Mus musculus 
2025-09-25 | GSE205612 | GEO
GenomicsIdentification of Ephrin type-B receptor 4 (EphB4) as a critical mediator of tissue fibrosis [RNA-seq]
Identification of Ephrin type-B receptor 4 (EphB4) as a critical mediator of tissue fibrosis [RNA-seq]
PRJNA846711 | ENA
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