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TranscriptomicsRNA-seq expression profiling of OCI-AML2 and OCI-AML3 cells upon CRISPR/Cas9 –mediated disruption of DDX3X RNA binding domain
Human acute myeloid leukemia cell lines OCI-AML2 and OCI-AML3 were used in a CRISPR/Cas9-mediated approach to specifically target DDX3X’s gene sequences encoding the RNA binding domain of the helicase. DDX3X RNA binding domain is bipartite in the two halves of the helicase core. sgRNAs were designed...
ORGANISM(S): Homo sapiens 
2019-11-23 | E-MTAB-6241 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human acute myeloid leukemia cell line OCI/AML2 with the anti-parasitic ivermectin
OCI AML2 cells were treated with the anti-parasitic ivermectin (single dose, two time points) in order to assess gene expression changes.
ORGANISM(S): Homo sapiens 
2010-01-06 | E-MEXP-2528 | biostudies-arrayexpress
GenomicsRNA-seq expression profiling of OCI-AML2 and OCI-AML3 cells upon CRIPSR/Cas9 –mediated disruption of DDX3X RNA binding domain
RNA-seq expression profiling of OCI-AML2 and OCI-AML3 cells upon CRIPSR/Cas9 –mediated disruption of DDX3X RNA binding domain
PRJEB23614 | ENA
OtherControl CRISPR screen from OCI-AML2 (ENCSR770ENU)
CRISPR-dCas9-based epigenomic regulatory element screening (CERES) technology to screen a subset of putative non-coding regulatory elements identified in human K562 leukemia cells from whole genome discovery screen (validation). This validation screen was performed in OCI-AML2 acute myeloid leukemia...
ORGANISM(S): Homo sapiens 
2026-02-28 | GSE321262 | GEO
Otherproliferation CRISPR screen from OCI-AML2 (ENCSR689KVW)
CRISPR-dCas9-based epigenomic regulatory element screening (CERES) technology to screen a subset of putative non-coding regulatory elements identified in human K562 leukemia cells from whole genome discovery screen (validation). This validation screen was performed in OCI-AML2 acute myeloid leukemia...
ORGANISM(S): Homo sapiens 
2026-02-28 | GSE321083 | GEO
GenomicsEffect of SOCS1 overexpression on AML gene expression in OCI-AML2 cell line
Effect of SOCS1 overexpression on AML gene expression in OCI-AML2 cell line
PRJNA1218726 | ENA
GenomicsGenome wide CRISPR screen for BET inhibitor resisatnce in OCI-AML2 cells using Y. Kosuke library
Genome wide CRISPR screen for BET inhibitor resisatnce in OCI-AML2 cells using Y. Kosuke library
PRJNA670198 | ENA
GenomicsGenome wide CRISPR screen for Venetoclax plus Ruxolitinib combination resistance in OCI-AML2 cells using Y. Kosuke library
Genome wide CRISPR screen for Venetoclax plus Ruxolitinib combination resistance in OCI-AML2 cells using Y. Kosuke library
PRJNA892071 | ENA
OtherGenome wide CRISPR screen for Venetoclax plus Ruxolitinib combination resistance in OCI-AML2 cells using Y. Kosuke library
30 million OCI-AML2 cells were infected with CRISPR/Cas9 library, selected for puromycin resistance for integration events and exposed DMSO, venetoclax (0.5 uM) or venetoclax (0.1 uM) plus ruxolitinib (1 uM).  Cells were collected at day 14 and 21 , DNA was extracted and sgRNA barcodes were amplifie...
ORGANISM(S): Homo sapiens 
2023-06-30 | GSE216087 | GEO
OtherGenome wide CRISPR screen for BET inhibitor resisatnce in OCI-AML2 cells using Y. Kosuke library
OCI-AML2 BETi-naive or JQ1 resistant cells were infected with CRISPR/Cas9 library, selected for puromycin resistance for integration events and exposed to JQ1/CPI-0610 or vehicle, DMSO, at 200nanoMolar for JQ1 and 500nanoMolar CPI-0610 concentrations. Cells were collected at time 0 (post puromycin s...
ORGANISM(S): Homo sapiens 
2023-10-13 | GSE159689 | GEO
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