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GenomicsOff-Target Analysis of Zinc Finger Nucleases
Zinc Finger Nucleases (ZFNs) facilitate precise editing of DNA enabling targeted genomic modifications in vivo. ZFNs have been employed to obtain genetically modified plants and animals, and cell-based therapies utilizing ZFNs are undergoing clinical trials. However, many ZFNs display dose-dependent...
ORGANISM(S): Danio rerio 
2010-08-25 | E-GEOD-23762 | biostudies-arrayexpress
GenomicsCas9 off-target binding to the promoter of bacterial genes leads to silencing and toxicity [RNA-Seq]
Cas9 off-target binding to the promoter of bacterial genes leads to silencing and toxicity [RNA-Seq]
PRJNA891751 | ENA
GenomicsCas9 off-target binding to the promoter of bacterial genes leads to silencing and toxicity [ChIP-Seq]
Cas9 off-target binding to the promoter of bacterial genes leads to silencing and toxicity [ChIP-Seq]
PRJNA896561 | ENA
GenomicsSelection of well-tolerated GalNAc-conjugated siRNAs by screening for RNAi-mediated off-target effects in rodent toxicity studies
Selection of well-tolerated GalNAc-conjugated siRNAs by screening for RNAi-mediated off-target effects in rodent toxicity studies
PRJNA428745 | ENA
TranscriptomicsCas9 off-target binding to the promoter of bacterial genes leads to silencing and toxicity [RNA-Seq]
Over the last decade, gene-silencing mediated by dCas9 binding to transcribed regions or their promoters, a strategy referred to as CRISPRi, has emerged as a powerful tool in bacterial genetics. While this strategy has already been broadly adopted, several studies have reported experimental setups i...
ORGANISM(S): Escherichia coli 
2022-10-25 | GSE216032 | GEO
GenomicsCas9 off-target binding to the promoter of bacterial genes leads to silencing and toxicity [ChIP-Seq]
Over the last decade, gene-silencing mediated by dCas9 binding to transcribed regions or their promoters, a strategy referred to as CRISPRi, has emerged as a powerful tool in bacterial genetics. While this strategy has already been broadly adopted, several studies have reported experimental setups i...
ORGANISM(S): Escherichia coli 
2022-11-04 | GSE217004 | GEO
OtherOff-Target Analysis of Zinc Finger Nucleases
Zinc Finger Nucleases (ZFNs) facilitate precise editing of DNA enabling targeted genomic modifications in vivo. ZFNs have been employed to obtain genetically modified plants and animals, and cell-based therapies utilizing ZFNs are undergoing clinical trials. However, many ZFNs display dose-dependent...
ORGANISM(S): Danio rerio 
2010-08-25 | GSE23762 | GEO
UnknownModeling and addressing on-target/off-tumor toxicity of claudin 18.2 targeted immunotherapies.
Not available
S-EPMC12579598 | biostudies-literature
UnknownA Combined In Vitro/In Silico Approach to Identifying Off-Target Receptor Toxicity.
Not available
S-EPMC6147237 | biostudies-literature
UnknownOn-target off-tumor toxicity of claudin18.2-directed CAR-T cells in preclinical models.
Not available
S-EPMC12579600 | biostudies-literature
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