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ProteomicsRegional identity of human neural stem cells determinesoncogenic responses to histone 1H3.3 mutants
Regional identity of human neural stem cells determinesoncogenic responses to histone 1H3.3 mutants
ORGANISM(S): Homo sapiens (Human) 
2021-09-09 | PXD021270 | Pride
Maxquant Q exactive plus Immunoprecipitation On-beads digest 
TranscriptomicsConstitutive activation of oncogenic PDGFR-mutants found in GIST patients induces receptor mislocalisation and alters PDGFR-A signalling characteristics
Gastrointestinal stomal tumors (GIST) are mainly characterised by the presence of activating mutations in either of the two receptor tyrosine kinases c-KIT and Platelet-derived growth factor receptor-a (PDGFRa). Most mechanistic studies dealing with GIST mutations have focused on c-KIT and far less ...
ORGANISM(S): Homo sapiens 
2015-11-11 | E-MTAB-2101 | biostudies-arrayexpress
UnknownGuanosine triphosphatase stimulation of oncogenic Ras mutants.
Not available
S-EPMC22057 | biostudies-literature
ProteomicsPharmacological Targeting of Casein Kinase 1δ Suppresses Oncogenic NRAS-Driven Melanoma
Activating mutations in NRAS account for 20-30% of melanoma, yet effective anti-NRAS therapies are still lacking. In this study, we unveil the casein kinase 1δ (CK1δ) as an uncharacterized regulator of oncogenic NRAS mutations, specifically Q61R and Q61K, which are the most prevalent NRAS mutations ...
ORGANISM(S): Homo sapiens (Human) 
2024-09-20 | PXD046277 | Pride
Oncogenic nras melanomagenesis  melanoma progression ck1δ  usp46. 
UnknownAntibody targeting intracellular oncogenic Ras mutants exerts anti-tumour effects after systemic administration.
Not available
S-EPMC5436137 | biostudies-literature
UnknownCryo-EM analyses of KIT and oncogenic mutants reveal structural oncogenic plasticity and a target for therapeutic intervention.
Not available
S-EPMC10068818 | biostudies-literature
UnknownLoss of peptidase D binding restores the tumor suppressor functions of oncogenic p53 mutants.
Not available
S-EPMC8655031 | biostudies-literature
ProteomicsMapping the Interactome of KRAS and Its G12C/D/V Mutants by Integrating TurboID Proximity Labeling with Quantitative Proteomics
RAS is one of the most frequently mutated proto-oncogenes in human malignancies, with mutation sites and subtypes exhibiting tumor-type dependent distribution. Oncogenic RAS mutations will maintain continuously GTP-bound activation states that leading to dysregulation of downstream signaling, ultima...
ORGANISM(S): Homo sapiens (Human) 
2025-06-09 | PXD062101 | Pride
Kras interactome  kras g12 mutants  turboid proximity-labeling  quantitative proteomics；metabolic reprogramming 
UnknownConstitutive asymmetric dimerization drives oncogenic activation of epidermal growth factor receptor carboxyl-terminal deletion mutants.
Not available
S-EPMC4496187 | biostudies-literature
UnknownMolecular assemblies of the catalytic domain of SOS with KRas and oncogenic mutants.
Not available
S-EPMC8000204 | biostudies-literature
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