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TranscriptomicsMolecular profiling of functional interactions between pre-osteoblastic and breast carcinoma cells
The relationships between cancer cells and the microenvironment play a critical role in cancer growth and development. The bone stroma consists of mesenchymal stem cells (MSCs) and mature osteoblasts that promote cancer growth. Yet it is not completely understood what are the molecular processes gui...
ORGANISM(S): Mus musculus 
2014-11-23 | E-GEOD-34529 | biostudies-arrayexpress
TranscriptomicsWnt inhibitory factor 1 (WIF1) is a marker of osteoblastic differentiation stage and is not silenced by DNA methylation in osteosarcoma
Purpose: We have used microarrays to identify gene expression profiles that distinguish mouse OS cells from normal pre-osteoblast cells and mature osteoblast cells. Methods: Transcriptional profiles of three cell lines derived from tumors from Osx-Cre p53fl/fl Rbfl/fl (fibroblastic OS) mouse model, ...
ORGANISM(S): Mus musculus 
2015-01-29 | E-GEOD-63939 | biostudies-arrayexpress
TranscriptomicsGenes modulated by rhBMP2 and rhBMP7 during osteoblastic differentiation of C2C12 cells
This study analyses the gene expression profile of pre-osteoblastic C2C12 mice cells during osteodifferentiation in control and induced by rhBMP2 and rhBMP7 using DNA microarrays. Genes which were already known to be activated by BMP2, to be also activated by rhBMP7, indicating that BMP7 induces the...
ORGANISM(S): Mus musculus 
2011-11-17 | E-GEOD-23783 | biostudies-arrayexpress
TranscriptomicsTranscriptome analysis of in vitro MSC-derived osteoblastic cells from patients with Primary Myelofibrosis
Primary myelofibrosis (PMF) is a clonal myeloproliferative neoplasm whose severity and treatment complexity is attributed to the presence of bone marrow (BM) fibrosis and alterations of stroma impairing the production of normal blood cells. Despite the recently discovered mutations including the JA...
ORGANISM(S): Homo sapiens 
2015-01-10 | E-GEOD-46021 | biostudies-arrayexpress
ProteomicsInterplay between cultured human osteoblastic and skeletal muscle cells: Effects of conditioned media on glucose and fatty acid metabolism
The interplay between skeletal muscle and bone is primarily mechanical, however, biochemical crosstalk by secreted mediators has recently gained increased attention. The aim of this study was to investigate metabolic effects of conditioned medium from osteoblasts (OB-CM) on myotubes and vice versa. ...
ORGANISM(S): Homo sapiens (Human) 
2024-01-26 | PXD045723 | Pride
Energy metabolism  myokines  osteoblastic cells  osteokines  primary human myotubes 
GenomicsExpression data from NPY Y1R-deficient osteoblastic cells
Expression data from NPY Y1R-deficient osteoblastic cells
PRJNA471505 | ENA
GenomicsAgeing in space: microgravity triggers ferroptosis and accelerates senescence in osteoblastic cells
Ageing in space: microgravity triggers ferroptosis and accelerates senescence in osteoblastic cells
PRJNA932730 | ENA
TranscriptomicsGenomic characterization of osteoblastic differentiation of MC-3T3E1 cells
Gene expression analysis of murine MC3T3-E1 cells induced to undergo synchronized osteoblastic differentiation in vitro. MC3T3-E1 cells were cultured in vitro for up to 28 days in the presence of 8-glycerol phosphate and ascorbic acid to induce osteoblastic differentiation. Total RNA was isolated a...
ORGANISM(S): Mus musculus 
2012-06-27 | E-GEOD-30393 | biostudies-arrayexpress
GenomicsMir-9-1 controls osteoblastic regulation of lymphopoiesis
Mir-9-1 controls osteoblastic regulation of lymphopoiesis
PRJNA998922 | ENA
TranscriptomicsExpression data from osteoblastic lineage cells isolated from normal and leukemic mice
Multipotent stromal cells (MSC) and their osteoblastic lineage cell (OBC) derivatives are part of the bone marrow (BM) niche and contribute to hematopoietic stem cell (HSC) maintenance. During myeloproliferative neoplasm (MPN) development, MSCs are stimulated to overproduce functtionally altered OBC...
ORGANISM(S): Mus musculus 
2013-07-11 | E-GEOD-48438 | biostudies-arrayexpress
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