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MetabolomicsReactive Oxygen Species Deficiency Due to Ncf1-Mutation Leads to Development of Adenocarcinoma and Metabolomic and Lipidomic Remodeling in a New Mouse Model of Dextran Sulfate Sodium-Induced Colitis
Inflammatory bowel disease is characterized by chronic relapsing idiopathic inflammation of the gastrointestinal tract and persistent inflammation. Studies focusing on the immune-regulatory function of reactive oxygen species (ROS) are still largely missing. In this study, we analyzed an ROS-deficie...
2019-05-22 | MTBLS593 | MetaboLights
TranscriptomicsTranscription profiling of Arabidopsis adaptive response to decreases in oxygen concentration in root
- Background and Aims: Oxygen can fall to low concentrations within plant tissues, either because of environmental factors that decrease the external oxygen concentration or because the movement of oxygen through the plant tissues cannot keep pace with the rate of oxygen consumption. Recent studies ...
ORGANISM(S): Arabidopsis thaliana 
2008-10-25 | E-GEOD-11558 | biostudies-arrayexpress
TranscriptomicsOxygen-dependent changes in gene expression in Campylobacter jejuni NCTC 11168
Oxygen transition experiement. Chemostat initially at steady state under oxygen replete conditions (7.5% oxygen input) was perturbed by a reduction in oxygen input (to 1.88% oxygen input). Samples were taken at the 7.5% oxygen and new 1.88% oxygen steady-states and at various points during the trans...
ORGANISM(S): Campylobacter jejuni subsp. jejuni NCTC 11168 
2017-10-04 | E-MTAB-5743 | biostudies-arrayexpress
MetabolomicsL-leucine increases the sensitivity of drug-resistant Salmonella to sarafloxacin by stimulating central carbon metabolism and increasing intracellular reactive oxygen species level (LC-MS positive mode)

The overuse of antibiotics has made public health and safety face a serious crisis. It is urgent to develop new clinical treatment methods to combat drug-resistant bacteria to alleviate the health crisis. The efficiency of antibiotics is closely related to the metabolic state of bacteria. However...

2023-05-02 | MTBLS7711 | MetaboLights
MetabolomicsL-leucine increases the sensitivity of drug-resistant Salmonella to sarafloxacin by stimulating central carbon metabolism and increasing intracellular reactive oxygen species level (LC-MS negative mode)

The overuse of antibiotics has made public health and safety face a serious crisis. It is urgent to develop new clinical treatment methods to combat drug-resistant bacteria to alleviate the health crisis. The efficiency of antibiotics is closely related to the metabolic state of bacteria. However...

2023-05-02 | MTBLS7713 | MetaboLights
TranscriptomicsHigh oxygen prevents fetal lethality due to lack of catecholamines
The catecholamine norepinephrine is required for fetal survival, but its essential function is unknown. When catecholamine-deficient [tyrosine hydroxylase (Th) null] mouse fetuses die at E13.5-E14.5, they resemble wild type fetuses exposed to hypoxia. They exhibit bradycardia (28% reduction in hear...
ORGANISM(S): Mus musculus 
2008-06-03 | E-GEOD-10341 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of Burkholderia cenocepacia J2315 grown under low or atmospheric oxygen concentration conditions
B. cenocepacia J2315 was grown on LB medium to mid-stationary phase at OD 0.3 under full aeration and then transferred into a 50 ml centrifuge tube and placed upright into a CampyGen Compact (Oxoid, Basingstoke, UK) plastic pouch containing the gas generating paper sachet. The pouch was sealed immed...
ORGANISM(S): Burkholderia cenocepacia 
2012-01-01 | E-MEXP-2787 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of Burkholderia cenocepacia J2315 was exposed to heat stress and to stress form reactive oxygen species
B. cenocepacia J2315 was exposed to heat stress and to stress form reactive oxygen species.
To expose the cultures to heat stress, cells were grown at 37ºC to an O.D. of 0.4 to 0.45 and then transferred into a different shaking incubator at 42.5ºC, incubated for 1 hour at 150 rpm and harvested.<...
ORGANISM(S): Burkholderia cenocepacia 
2012-01-01 | E-MEXP-2791 | biostudies-arrayexpress
TranscriptomicsGene expression microarray analysis of early oxygen-induced retinopathy (OIR)
Different inbred strains of rats differ in their susceptibility to OIR, an animal model of human retinopathy of prematurity. We examined gene expression profiles in Fischer 344 (F344, resistant to OIR) and Sprague Dawley (SD, susceptible to OIR) rats at the early time point of day 3 to identifying g...
ORGANISM(S): Rattus norvegicus 
2009-11-12 | E-GEOD-18998 | biostudies-arrayexpress
GenomicsRespiratory backpressure determines normoxic distribution of terminal oxygen reduction pathways
Respiratory backpressure determines normoxic distribution of terminal oxygen reduction pathways
PRJNA704580 | ENA
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