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TranscriptomicsDisruption of PPARg signaling results in mouse prostatic intraepithelial neoplasia (mPIN) involving active autophagy
Peroxisome proliferator-activated receptor-gamma (PPARg) regulates the interface between cellular lipid metabolism, redox status and organelle differentiation. Following conditional prostatic epithelial knockout of PPARg in mice we observed focal hyperplasia of the epithelium which developed to mous...
ORGANISM(S): Mus musculus 
2010-05-18 | E-GEOD-13867 | biostudies-arrayexpress
TranscriptomicsImage based identification and targeting of cancer stem cells in pancreatic adenocarcinoma
Pancreatic intraepithelial neoplasia (PanIN) is a premalignant lesion that can progress to pancreatic ductal adenocarcinoma, a highly lethal malignancy marked by its late stage at clinical presentation and profound drug resistance. Here we developed novel fluorescent reporter mice that show that the...
ORGANISM(S): Mus musculus 
2016-06-15 | E-GEOD-73312 | biostudies-arrayexpress
ProteomicsLCM based proteomics of pancreatic intraepithelial neoplasia and adjacent normal tissues
Pancreatic intraepithelial neoplasia and adjacent normal tissues were isolated by laser capture microdissection and analyzed by 4D-DIA proteomics.
ORGANISM(S): Homo Sapiens 
2024-09-21 | PXD056113 |
TranscriptomicsBrg1 promotes both tumor suppressive and oncogenic activities at distinct stages of Pancreatic cancer formation
Pancreatic Ductal Adenocarcinoma (PDA) develops predominantly through pancreatic intraepithelial neoplasia (PanIN) and intraductal papillary mucinous neoplasm (IPMN) precursor lesions. Pancreatic acinar cells are reprogrammed to a “ductal like” state during PanIN-PDA formation. Here, we demonstrate ...
ORGANISM(S): Mus musculus 
2015-07-29 | E-GEOD-65315 | biostudies-arrayexpress
TranscriptomicsExpression analysis of a preinvasive pancreatic cancer mouse model with and without p120 catenin
Pancreatic cancer is one of the most deadly cancers with a 5 year survival rate of about 5%. Therapeutic options are limited, especially for patients that present with late state disease and metastasis. Although the metastatic burden of pancreatic cancer is usually high, little is known about the ...
ORGANISM(S): Mus musculus 
2016-07-25 | E-GEOD-68090 | biostudies-arrayexpress
UnknownIL2RG, identified as overexpressed by RNA-seq profiling of pancreatic intraepithelial neoplasia, mediates pancreatic cancer growth.
Not available
S-EPMC5663522 | biostudies-literature
GenomicsSpatial Proteomics and Transcriptomics Reveal Early Immune Cell Organization in Pancreatic Intraepithelial Neoplasia
Spatial Proteomics and Transcriptomics Reveal Early Immune Cell Organization in Pancreatic Intraepithelial Neoplasia
PRJNA1251073 | ENA
UnknownReconstituting development of pancreatic intraepithelial neoplasia from primary human pancreas duct cells.
Not available
S-EPMC5344977 | biostudies-literature
UnknownGenome-Wide Somatic Copy Number Alterations and Mutations in High-Grade Pancreatic Intraepithelial Neoplasia.
Not available
S-EPMC6024190 | biostudies-literature
TranscriptomicsGene expression alterations of pancreatic intraepithlial neoplasia
Gene expression data from the RNA sequencing of laser microdissected pancreatic intraepithelial neoplasia and pancreatic normal ducts.
ORGANISM(S): Homo sapiens 
2018-03-17 | GSE96784 | GEO
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