parkinson's disease

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Unknown (19895)
Genomics (763)
Transcriptomics (617)
Proteomics (325)
Metabolomics (33)
Models (24)
Methylation profiling (17)
Genomic (11)
Other (7)
Clinical (3)
Multiomics (1)

Organisms

Homo sapiens (500)
Mus musculus (166)
Rattus norvegicus (38)
Drosophila melanogaster (21)
Carassius auratus (8)
Danio rerio (8)
Caenorhabditis elegans (7)
Streptomyces venezuelae (6)
Arabidopsis thaliana (6)
Bos taurus (4)
Escherichia coli (4)
Saccharomyces cerevisiae (4)
Teleopsis quinqueguttata (3)
Canis lupus familiaris (2)
Sphyracephala beccarii (2)
Xerophyta humilis (2)
Aplysia californica (2)
Lepidium sativum (2)
Oryza sativa Japonica Group (2)
Felis catus (1)
cellular organisms (1)
Hypericum perforatum (1)
Bathyergus suillus (1)
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Drosophila hawaiiensis (1)
Delphinapterus leucas (1)
Microbacterium oxydans (1)
Heliothis virescens (1)
Gambusia holbrooki (1)
Cyanidioschyzon merolae (1)

Organisms

Homo sapiens (257)
Mus musculus (92)
Rattus norvegicus (20)
human gut metagenome (12)
mouse gut metagenome (5)
Drosophila melanogaster (5)
Caenorhabditis elegans (4)
Mus (3)
human feces metagenome (3)
feces metagenome (3)
Danio rerio (3)
gut metagenome (2)
Saccharomyces cerevisiae (2)
Mucuna pruriens var. utilis (1)
Clostridium butyricum (1)
Proteus mirabilis (1)
Eubacterium callanderi (1)
unidentified (1)
Ligilactobacillus animalis (1)
Rattus rattus (1)
synthetic RNA (1)
Chlorocebus sabaeus (1)
Bacteria (1)
human metagenome (1)
Macaca fascicularis (1)
mouse metagenome (1)
human oral metagenome (1)

Repository

ENA (639)
biostudies-arrayexpress (417)
geo (308)
pride (226)
MassIVE (42)
EGA (38)
MetaboLights (28)
BioModels (22)
iProX (21)
ExpressionAtlas (12)
jPOST (12)
dbGaP (11)
PanoramaPublic (7)
GNPS (3)
EVA (2)
MetabolomicsWorkbench (2)
PAXDB (2)
PeptideAtlas (2)
PMR (2)
GPMDB (1)

Tissue

Brain (94)
Blood (5)
Prefrontal cortex (4)
Adipose tissue (1)
Adrenal cortex (1)
Amygdala (1)
Aorta (1)
Body of tongue (1)
Bone marrow (1)
Breast (1)
Bronchus (1)
Caecum (1)
Cardia of stomach (1)
Cardiac atrium (1)
Cardiac ventricle (1)
Caudate nucleus (1)
Cerebellar hemisphere (1)
Cerebellar vermis (1)
Cerebellum (1)
Cerebral cortex (1)
Colon (1)
Coronary artery (1)
Corpus callosum (1)
Cortex of kidney (1)
Deltoid (1)
Dorsal plus ventral thalamus (1)
Dorsal root ganglion (1)
Duodenum (1)
Endometrium (1)
Esophagus (1)

Disease

Parkinson's disease (206)
Alzheimer's disease (13)
Normal (10)
Lewy body dementia (7)
Multiple system atrophy (5)
Adenocarcinoma (1)
Adenomyosis (1)
Alzheimers disease (1)
Amyotrophic lateral sclerosis (1)
Amyotrophic lateral sclerosis with dementia (1)
Benign prostatic hyperplasia (1)
Breast cancer (1)
Control (1)
Corticobasal degeneration (1)
Corticobasal degeneration (1)
Endometriosis (1)
Essential tremor (1)
Genetic frontotemporal degeneration with FUS inclusions (1)
Genetic frontotemporal degeneration with TDP inclusions (1)
Genetic frontotemporal degeneration with dementia (1)
Genetic frontotemporal degeneration with ubiquitin inclusions (1)
Hepatocellular carcinoma (1)
Melanoma (1)
Neuromuscular pain (1)
None (1)
Parkinson's disease and Parkinson's disease dementia (1)
Pathological aging (1)
Pick disease (1)
Progressive supranuclear palsy (1)
Tangle predominant senile dementia (1)

Technology Type

Mass Spectrometry (228)
Shotgun proteomics (111)
Bottom-up proteomics (45)
Affinity purification coupled with mass spectrometry proteomics (23)
SWATH MS (21)
Data-dependent acquisition (17)
Data-independent acquisition (17)
Mass spectrometry (16)
SRM/MRM (10)
Gel-based experiment (8)
Mass spectrometry assay (7)
Chemical cross-linking coupled with mass spectrometry proteomics (5)
Top-down proteomics (5)
NMR spectroscopy (3)
Illumina HiSeq 2000 (2)
NMR spectroscopy assay (2)
HDMSE (2)
ILLUMINA, Illumina HiSeq 2000 (1)
Illumina 1.2M, Illumina 610K Quad, Affymetrix 6.0 (1)
EI (1)
ESI (1)
All-ion fragmentation (1)
Mass spectrometry imaging (1)

Instrument Platform

Illumina NovaSeq 6000 (19)
NextSeq 500 (12)
Illumina HiSeq 2000 (11)
Illumina HiSeq 4000 (7)
Illumina NovaSeq X (6)
Illumina HiSeq 2500 (5)
Illumina Genome Analyzer IIx (3)
- (3)
Sequel (2)
NA (2)
Illumina MiSeq (2)
NextSeq 550 (2)
Illumina HiSeq 3000 (2)
Tapestri Platform (1)
Pacbio Revio (1)
-- (1)
Linux Bash Scripting (1)
NEBNext Ultra II Directional RNA Library Prep (1)
Qiagen RNeasy Mini Kit (1)
With L-glutamine supplemented with 10% fetal bovine serum (FBS) (Gibco) and 1% penicillin-streptomycin (10,000 units/mL penicillin and 10 mg/mL streptomycin) (Gibco). (1)
Sequel II (1)
Affymetrix miRNA 3.1 (1)
Not Applicable (1)
Not Applicablre (1)
Other (1)
Axon- GenePix4000B (1)
R (1)
TruSeq (Illumina, Novogene, Genomic Centre Cambridge, CB4 0FW, UK.) (1)
NanoDrop spectrophotometer and the Agilent 2100 Bioanalyzer (1)
Histopaque-1077,FACSAria Fusion Sorter,Flow Cytometer (1)

Publication Date

2026 (112)
2025 (108)
2024 (82)
2022 (72)
2023 (64)
2015 (63)
2016 (62)
2010 (62)
2014 (59)
2021 (58)
2013 (56)
2012 (56)
2011 (51)
2020 (47)
2018 (36)
2019 (29)
2017 (29)
2008 (26)
2009 (9)
2007 (8)
2004 (5)
2006 (4)
2005 (3)
2002 (1)

UNIPROT ID/AC

P37840 (8)
O60260 (3)
P09936 (3)
A0AVT1 (3)
P20711 (2)
P21397 (2)
P0CG47 (2)
P07101 (2)
P13473 (2)
Q9BXM7 (1)
G4XXL9 (1)
Q99497 (1)
O95140 (1)
P14416 (1)
Q49A63 (1)
B3KTS5 (1)
P21796 (1)
Q5U5U6 (1)
O43464 (1)
Q53FS6 (1)
B4DR68 (1)
F5H897 (1)
Q12931 (1)
O60218 (1)
H6UYS5 (1)
L7RSM2 (1)
P49459 (1)
Q5VVX4 (1)
P78417 (1)
P11142 (1)

ENSEMBL ID

ENSG00000170477 (2)
ENSG00000158828 (1)
ENSG00000154277 (1)
ENSG00000151552 (1)
ENSG00000116288 (1)
ENSG00000116688 (1)
ENSG00000142319 (1)
ENSG00000149295 (1)
ENSG00000213585 (1)
ENSG00000115317 (1)
ENSG00000093010 (1)
ENSG00000126602 (1)
ENSG00000180176 (1)
ENSG00000198074 (1)
ENSG00000111275 (1)
ENSG00000145335 (1)
ENSG00000112062 (1)
ENSG00000077721 (1)
ENSG00000132437 (1)
ENSG00000185345 (1)
ENSG00000033178 (1)
ENSG00000147251 (1)
ENSG00000247315 (1)

CHEBI ID

CHEBI:15422 (9)
CHEBI:16761 (8)
CHEBI:15741 (6)
CHEBI:16856 (6)
CHEBI:15765 (5)
CHEBI:18243 (4)
CHEBI:16474 (4)
CHEBI:16908 (4)
CHEBI:15846 (4)
CHEBI:18237 (4)
CHEBI:17895 (4)
CHEBI:18012 (4)
CHEBI:60425 (3)
CHEBI:26523 (3)
CHEBI:15356 (3)
CHEBI:16680 (3)
CHEBI:41941 (3)
CHEBI:17858 (3)
CHEBI:59560 (2)
CHEBI:60027 (2)
CHEBI:27978 (2)
CHEBI:545959 (2)
CHEBI:25212 (2)
CHEBI:15414 (2)
CHEBI:18421 (2)
CHEBI:29034 (2)
CHEBI:29033 (2)
CHEBI:16240 (2)
CHEBI:15377 (2)
CHEBI:15379 (2)

Metabolite Name

Taurine (7)
Creatine (7)
Creatinine (6)
Lactate (5)
Choline (5)
Glycine (5)
Carnitine (5)
Hypoxanthine (5)
2-Hydroxyisovalerate (4)
Acetoacetate (4)
3-Hydroxybutyrate (4)
2-Hydroxybutyrate (4)
Pyroglutamate (4)
Glycerol (4)
L-Alanine (4)
Urea (4)
L-Serine (4)
Pyruvate (4)
Betaine (4)
Adenine (4)
Tryptophan (4)
Anserine (4)
Alanine (4)
Phenylalanine (4)
Uracil (4)
Leucine (4)
Inosine (4)
Methionine (4)
Ethanolamine (3)
Dimethylamine (3)

First Public Date

2025 (91)
2026 (90)
2024 (87)
2014 (66)
2022 (52)
2021 (52)
2023 (48)
2020 (42)
2018 (22)
2017 (19)
2016 (19)
2013 (19)
2019 (18)
2015 (14)

Modelling Approach

Ordinary differential equation model (20)

Study status

Not yet recruiting (2)
Recruiting (1)

Lab affiliation

Paris-Saclay Institute of Neuroscience, Team Melki, CNRS, Gif-sur-Yvette, France (8)
Harvard Medical School Cell Biology Department (3)
Borch Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, Indiana 47907, United States Purdue Institute for Integrative Neuroscience, Purdue University, West Lafayette, Indiana 47907, United States (2)
Department of Biochemistry and Molecular Biology, Protein Research group, University of Southern Denmark, Odense, Denmark (2)
Department of Neurology Institute for Cell Engineering Johns Hopkins University School of Medicine (2)
Department of Oncology-Pathology, Karolinska Institutet and Science for Life Laboratory, Stockholm, Sweden (2)
Instituto de Biomedicina de Sevilla (IBiS)-CSIC (2)
Max Planck Institute of Biochemistry (2)
Rush University Medical Center (2)
Structural Biology & Developmental Neurobiology Director, St. Jude Proteomics Facility St. Jude Children's Research Hospital 262 Danny Thomas Place, Memphis, TN 38105 (2)
Université de Montréal (2)
- Inst. of Neuroscience and Physiology, Dept. of Psychiatry and Neurochemistry, The Sahlgrenska Academy at University of Gothenburg, Mölndal, Sweden - Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden - Department of Molecular Neuroscience, UCL Institute of Neurology, Queen Square, London, UK (1)
1. Department of Pharmacology & Therapeutics, McGill University, Montréal, Québec, Canada 2. Centre de Recherche en Biologie Structurale, Montréal, Québec, Canada (1)
1. German Center for Neurodegenerative Diseases (DZNE), 89081 Ulm, Germany 2. Department of Neurology, University Clinic Ulm, 89081 Ulm, Germany (1)
1. Institute of Clinical Chemistry, University Medical Center Goettingen, Goettingen, Germany; 2. Bioanalytical Mass Spectrometry Group, Max Planck Institute for Biophysical Chemistry, Goettingen, Germany (1)
1. Shengli Clinical Medical College of Fujian Medical University, Fujian Provincial Hospital, Fuzhou University Affiliated Provincial Hospital, Department of Neurology, Fuzhou 350108, China 2.School of Medicine, The Chinese University of Hong Kong, Shenzhen 518172, China (1)
1Human Embryonic and Induced Pluripotent Stem Cell Unit, Hellenic Pasteur Institute, Athens, Greece 2Laboratory of Cellular and Molecular Neurobiology-Stem Cells, Hellenic Pasteur Institute, Athens, Greece (1)
ADLQ (1)
Appel Alzheimer's Disease Research Institute & Brain and Mind Research Institute Weill Cornell Medicine New York, NY USA (1)
Assistant Professor of Genetics Genetics Department University of Pennsylvania 5050 Colket Translational Research Building 3501 Civic Center Boulevard Philadelphia, PA 19104 (1)
Associate Professor of Neurology and Neuroscience (1)
Associate Professor, Neuroscience, The Scripps Research Institute Florida (1)
Bioanalytical Mass Spectrometry Group, Max-Planck Institute for Multidisciplinary Sciences, Am Fassberg 11, 37077 Goettingen; Institute for Clinical Chemistry, University Medical Center Goettingen, Robert-Koch-Str. 40, 37075 Goettingen (1)
Biochemistry and Molecular Biophysics Graduate Group, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. Children's Hospital of Philadelphia Research Institute, Philadelphia, PA 19104, USA. (1)
Biochemistry and Molecular Biophysics Graduate Group, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA (1)
Biochemistry, Boston University (1)
Bioinformatics Scientist Van Andel Institute (1)
Biomedical Research Institute, Foundation for Research and Technology-Hellas, Ioannina, Greece. (1)
Biomolecular Mass Spectrometry and Proteomics, Bijvoet Center for Biomolecular Research and Utrecht Institute for Pharmaceutical Sciences, University of Utrecht, Padualaan 8, Utrecht 3584 CH The Netherlands Netherlands Proteomics Center, Padualaan 8, Utrecht 3584 CH, The Netherlands (1)
Biotech Research and Innovation Centre (BRIC), University of Copenhagen, Copenhagen, Denmark (1)

Keyword

Diabete Mellitus (1)
Sickle Cell Disease (1)
Sjogren’s Syndrome (1)

IsPrivate

False (22)

Model Flag

Non Kinetic (3)

Classification

bacteria (2)

Modification

Not available (1)

Study type

Transcription profiling by array (235)
RNA-seq of coding RNA (65)
ChIP-seq (22)
Comparative genomic hybridization by array (13)
RNA-seq of non coding RNA (8)
High-throughput sequencing (7)
Transcription profiling by tiling array (7)
Proteomic profiling by array (7)
RNA-seq of coding RNA from single cells (7)
Other (6)
ChIP-chip by array (5)
Methylation profiling by high throughput sequencing (5)
RNA-seq of total RNA (5)
Unknown experiment type (4)
Genotyping by array (4)
MicroRNA profiling by array (3)
DNA-seq (3)
Transcription profiling by SAGE (2)
Cell line - One-color microarray (2)
Cell line - High-throughput sequencing (2)
Observational (2)
ChIP-chip by tiling array (1)
RNAi profiling by array (1)
Bisulfite-seq (1)
ScATAC-seq (1)
Genotyping by high throughput sequencing (1)
Interventional (1)

Release Date

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2022 (2440)
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2024 (2145)
2021 (2128)
2020 (1679)
2019 (1215)
2018 (1035)
2017 (910)
2016 (789)
2015 (663)
2014 (605)
2013 (361)
2026 (331)
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2011 (265)
2010 (207)
2009 (119)
2008 (109)
2007 (66)
2006 (35)
2004 (26)
2005 (23)
2003 (13)
2002 (11)
2000 (6)
2001 (5)
1999 (3)
1998 (3)

Location

New Zealand (1)
Australia (1)
United States (1)

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Metabolomics of sebum reveals lipid dysregulation in Parkinson's disease

Parkinson's disease (PD) is a progressive neurodegenerative disorder, which is characterised by degeneration of distinct neuronal populations, including dopaminergic neurons of the substantia nigra. Here, we use a metabolomics profiling approach to identify changes to lipids in PD observed in sebum,...

2020-12-21 | MTBLS2266 | MetaboLights

Mouse striatal neurotransmitter metabolomics profiling reveals bacteriophage-mediated restoration of levodopa responsiveness in Parkinson's disease

Targeted LC-MS/MS metabolomics profiling was performed on mouse striatal tissues to investigate neurotransmitter metabolic alterations associated with bacteriophage-mediated restoration of levodopa responsiveness in Parkinson's disease. Striatal samples were collected from Parkinson's disease mouse ...

2026-10-19 | MTBLS14915 | MetaboLights

Integrative Metabolomics-GWAS Mendelian Randomization Reveals Causal Metabolic and Inflammatory Drivers of Parkinson's Disease

Parkinson's disease (PD) is the second most common neurodegenerative disorder, characterized by a complex pathogenesis involving the interplay of multiple molecular and cellular pathways. In recent years, metabolic dysregulation and neuroinflammation have been recognized as key contributors to PD...

2025-11-05 | MTBLS13269 | MetaboLights

Targeted Bile Acid Metabolomic Profiling of Plasma Samples in Patients with Parkinson's Disease

Targeted LC-MS metabolomic profiling was performed on plasma samples from a validation cohort comprising 20 patients with Parkinson's disease and 20 healthy controls. The study aimed to verify altered circulating bile acid levels identified in the discovery cohort, assess correlations between bil...

2026-09-03 | MTBLS15429 | MetaboLights

Aerobic exercise and gut flora: a key link to improved cognitive impairment in mice with Parkinson's disease

Parkinson's disease (PD) is a common neurodegenerative disorder. It is marked by motor dysfunction and cognitive decline. In recent years, scientific studies have found that PD's pathogenesis may be tied to an imbalance in the gut microbiota. This offers new perspectives for PD treatment. Modulat...

2025-10-12 | MTBLS13123 | MetaboLights

Alterations of fecal microbiota and plasma metabolome in patients with Parkinson's disease with rapid eye movement sleep disorder

Objectives: Patients with Parkinson's disease (PD) with probable Rapid eye movement sleep Behavior Disorder (RBD) (PD-RBD), a specific subtype of PD, is characterized by the presence of more severe motor and non-motor symptoms. This study aimed to elucidate the characteristics and interactions of...

2025-05-07 | MTBLS11094 | MetaboLights

Metabolic Profiling of CSF from People Suffering from Sporadic and LRRK2 Parkinson's Disease: A Pilot Study

CSF from unique groups of Parkinson's disease (PD) patients was biochemically profiled to identify previously unreported metabolic pathways linked to PD pathogenesis, and novel biochemical biomarkers of the disease were characterized. Utilizing both 1H NMR and DI-LC-MS/MS we quantitatively profiled ...

2022-09-02 | MTBLS863 | MetaboLights

Plasma metabolomics data in the Wenzhou Parkinson's disease cohort

To discriminate plasma metabolomic profiles between Parkinson’s disease (PD) and healthy controls (HC) in Wenzhou, China, we performed liquid chromatography–mass spectrometry (LC–MS) analysis in a cohort comprising 140 PD patients and 72 HC participants. Plasma samples were subjected to LC–MS metabo...

2026-08-24 | MTBLS15442 | MetaboLights

NR-SAFE: a randomized, double-blind safety trial of high dose nicotinamide riboside in Parkinson's disease

Nicotinamide adenine dinucleotide (NAD) replenishment therapy using nicotinamide riboside (NR) shows promise for Parkinson’s disease (PD) and other neurodegenerative disorders. However, the optimal dose of NR remains unknown, and doses exceeding 2000 mg daily have not been tested in humans. To ev...

2025-04-09 | MTBLS8812 | MetaboLights

Transcriptional analysis of multiple brain regions in Parkinson's disease

Transcriptional analysis of multiple brain regions in Parkinson's disease supports the involvement of specific protein processing, energy metabolism, and signaling pathways, and suggests novel disease mechanisms. This SuperSeries is composed of the following subset Series: GSE20168: Transcriptional...

ORGANISM(S): Homo sapiens

2010-03-23 | E-GEOD-20295 | biostudies-arrayexpress

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