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MetabolomicsIdentifying glycolysis in mitochondria as a new perspective on the pathogenesis of retinitis pigmentosa
Identifying glycolysis in mitochondria as a new perspective on the pathogenesis of retinitis pigmentosa
2026-03-28 | MTBLS14170 | MetaboLights
MetabolomicsIdentifying glycolysis in mitochondria as a new perspective on the pathogenesis of retinitis pigmentosa
Identifying glycolysis in mitochondria as a new perspective on the pathogenesis of retinitis pigmentosa.
2026-03-29 | MTBLS14179 | MetaboLights
MetabolomicsDifferentiation Defect Repositions Sebaceous Glands as Instigators in the Early Pathogenesis of Hidradenitis Suppurativa

The role of sebaceous glands (SGs) in the early pathogenesis of hidradenitis suppurativa (HS) is undefined, with unclear causal relationship to inflammatory sequelae. The aim of this study was to determine whether SG aberrations constitute a primary pathogenic driver in early HS and elucidate the...

2025-12-28 | MTBLS13578 | MetaboLights
MetabolomicsMulti-omics analysis identifies gut microbiota-glutamine axis contributing to the pathogenesis of reflux esophagitis

Background: Reflux esophagitis (RE), a common gastroesophageal reflux disease characterized by esophageal mucosal inflammation, is closely associated with gut microbiota dysbiosis and metabolic abnormalities. The glutamine-glutamate metabolic pathway regulates inflammation and mucosal barrier fun...

2026-05-03 | MTBLS14421 | MetaboLights
MetabolomicsMulti-omics analysis reveals microbiota-metabolite crosstalk in MASLD pathogenesis in a non-obese murine model

The rising global prevalence of metabolic dysfunction-associated steatotic liver disease (MASLD), including its severe form metabolic dysfunction-associated steatohepatitis (MASH), underscores the urgency to elucidate its pathophysiology. To investigate key metabolic interactions central to MASLD...

2026-03-13 | MTBLS14048 | MetaboLights
MetabolomicsG6PD deficiency triggers dopamine loss and the initiation of Parkinson’s Disease pathogenesis
Loss of dopaminergic neurons in Parkinson’s disease (PD) is preceded by loss of synaptic dopamine (DA) and accumulation of proteinaceous aggregates. Linking these deficits is critical to restoring DA signaling in PD. Using murine and human pluripotent stem cell (hPSC) models of PD coupled with human...
2024-10-18 | MTBLS11250 | MetaboLights
MetabolomicsChanges in the Abundance of the Fecal Microbiota are Implicated in the Pathogenesis of Diarrhea in Yak Calves

The yak, an economically vital species on the Qinghai-Tibet Plateau, faces a significant challenge with diarrhea during the calf stage. However, studies about diarrhea of yak calves were few. Due to the close link between diarrhea and intestinal microbiota. Therefore, this study analyzed the feca...

2026-06-03 | MTBLS13964 | MetaboLights
MetabolomicsDisrupted intestinal microbiota contributes to the pathogenesis of anorexia nervosa (Part 1)
Not available
ORGANISM(S): Homo sapiens 
ST002494 | MetabolomicsWorkbench
MetabolomicsDisrupted intestinal microbiota contributes to the pathogenesis of anorexia nervosa (Part 2)
Not available
ORGANISM(S): Homo sapiens 
ST002495 | MetabolomicsWorkbench
MetabolomicsMetabolic profiling reveals biochemical pathways and potential biomarkers associated with the pathogenesis of Krabbe disease
Not available
ORGANISM(S): Mus musculus 
ST000352 | MetabolomicsWorkbench
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