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MetabolomicsFrom Herbarium to life: Implications of Reviving Historical Fungi for Modern Plant Pathology and Agriculture.
The Green Revolution (GR) profoundly altered plant–microorganism interactions through widespread agrochemical use and crop breeding. Phytopathogenic fungi present major challenges to agriculture by reducing yield and quality, increasing production costs, and impacting food security and environmental...
2025-06-10 | MTBLS12551 | MetaboLights
MetabolomicsNeuronal Hyperactivity due to Loss of Inhibitory Tone in APOE4 Mice Lacking Alzheimer’s Disease-like Pathology
Metabolite profiling was performed on metabolites extracted from the entorhinal cortex and primary visual cortex of 14-15 month old APOE3/3, APOE3/4 and APOE4/4 mice. Metabolites were run on a TOF Mass Spectrometer using an ANP column. Initial analysis was done in an untargeted manner, and processin...
2017-09-05 | MTBLS530 | MetaboLights
Metabolomics1H NMR Metabolomics Identifies Underlying Inflammatory Pathology in Osteoarthritis and Rheumatoid Arthritis Synovial Joints
Despite osteoarthritis (OA) and rheumatoid arthritis (RA) being typically age-related, their underlying etiologies are markedly different. We used 1H nuclear magnetic resonance (NMR) spectroscopy to identify differences in metabolite profiles in low volumes of OA and RA synovial fluid (SF). SF was a...
2018-10-11 | MTBLS564 | MetaboLights
MetabolomicsNLRP3 Senses L-Arginine to Inhibit Inflammasome Activation and Alleviate Parkinson’s disease Pathology

We screened a series of metabolites and found that L-Arg strongly inhibits NLRP3 inflammasome assembly in vitro. Mechanistically, L-Arg directly binds the D31 site of NLRP3, blocking NLRP3-ASC interaction and subsequent inflammasome assembly. This discovery establishes NLRP3 as a direct sensor fo...

2026-09-02 | MTBLS13737 | MetaboLights
MetabolomicsPlasma sphingolipid changes with autopsy-confirmed Lewy body or Alzheimer's pathology
Not available
ORGANISM(S): Homo sapiens 
ST000433 | MetabolomicsWorkbench
MetabolomicsAPOE modulates microglial immunometabolism in response to age, amyloid pathology, and inflammatory challenge (Part 3 of 3)
Not available
ORGANISM(S): Mus musculus 
ST002453 | MetabolomicsWorkbench
MetabolomicsAPOE modulates microglial immunometabolism in response to age, amyloid pathology, and inflammatory challenge (Part 2 of 3)
Not available
ORGANISM(S): Mus musculus 
ST002451 | MetabolomicsWorkbench
MetabolomicsAPOE modulates microglial immunometabolism in response to age, amyloid pathology, and inflammatory challenge (Part 1 of 3)
Not available
ORGANISM(S): Mus musculus 
ST002450 | MetabolomicsWorkbench
MetabolomicsDietary inclusion of nitrite-containing frankfurter exacerbates colorectal cancer pathology, increases oxidative stress, alters metabolism and causes gut dybiosis in APCmin mice
Not available
ORGANISM(S): Mus musculus 
ST002313 | MetabolomicsWorkbench
UnknownCurrent opinion, status and future development of digital pathology in Switzerland.
Not available
S-EPMC9609370 | biostudies-literature
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