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ProteomicsElongator is required for pattern recognition receptor and type I interferon signaling in macrophages.
Innate immune detection of pathogens by macrophages requires a rapid and large scale mobilisation of cellular resources towards an appropriate immune response, mainly involving altered protein expression. Pathogen recognition is mediated by pattern recognition receptor (PRR) sensing of conserved mic...
ORGANISM(S): Mus musculus (Mouse) 
2025-12-22 | PXD064630 | Pride
Innate immunity  interferon  interferon regulatory factor (irf)  lipopolysaccharide (lps)  macrophage  pattern recognition receptor (prr)  stat transcription factor  toll-like receptor 4 (tlr4)  virus  elongator 
TranscriptomicsTranscriptional profile of WT, PRR and IFN-/- dendritic cells stimulated with poly IC in vivo
Analysis of the specific transcriptional changes on DCs provided by direct pattern recogition receptor (PRR) or IFNAR signaling that are required for DC maturation after poly IC stimulation. Results provide important information about the intricate differentiation process of DC maturation and the im...
ORGANISM(S): Mus musculus 
2013-10-01 | E-GEOD-46478 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of naïve bone marrow-resident granulocyte monocyte precursors (GMPs) and TSLP-elicited splenic GMP-like cells
Extramedullary hematopoiesis (EMH) refers to the differentiation of hematopoietic stem cells (HSCs) into effector cells that occurs in compartments outside of the bone marrow. Previous studies linked pattern recognition receptor (PRR)-expressing HSCs, EMH and immune responses to microbial stimuli. H...
ORGANISM(S): Mus musculus 
2014-03-28 | E-GEOD-52485 | biostudies-arrayexpress
UnknownA UK Biobank Study on Genetic Variants in Pattern-Recognition Receptor (PRR) Signaling Indicates Self-Perpetuatin Inflammation of Cholesteatoma.
Not available
S-EPMC12941801 | biostudies-literature
UnknownEvolutionary gain and loss of a plant pattern-recognition receptor for HAMP recognition.
Not available
S-EPMC9718524 | biostudies-literature
UnknownAvian Pattern Recognition Receptor Sensing and Signaling.
Not available
S-EPMC7157566 | biostudies-literature
GenomicsATAC-seq analysis of immune responses from bone marrow derived dendritic cells stimulated with 7 pattern recognition receptor (PRR) ligands along with their pairwise and triplet combinations
ATAC-seq analysis of immune responses from bone marrow derived dendritic cells stimulated with 7 pattern recognition receptor (PRR) ligands along with their pairwise and triplet combinations
PRJNA556659 | ENA
UnknownDM9 Domain Containing Protein Functions As a Pattern Recognition Receptor with Broad Microbial Recognition Spectrum.
Not available
S-EPMC5712788 | biostudies-literature
UnknownDynamin-Related Proteins Enhance Tomato Immunity by Mediating Pattern Recognition Receptor Trafficking.
Not available
S-EPMC9415932 | biostudies-literature
GenomicsRNA-seq analysis of immune responses from mouse bone marrow derived dendritic cells stimulated with 7 pattern recognition receptor (PRR) ligands along with their pairwise and triplet combinations
RNA-seq analysis of immune responses from mouse bone marrow derived dendritic cells stimulated with 7 pattern recognition receptor (PRR) ligands along with their pairwise and triplet combinations
PRJNA556660 | ENA
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