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ProteomicsPAXIP1 and STAG2 converge to maintain 3D genome archi-tecture and facilitate promoter/enhancer contacts to enable stress hormone-dependent transcription
How steroid hormone receptors (SHRs) orchestrate transcriptional activity remains only partly understood. Upon activation, SHRs bind the genome and recruit their co-regulators, crucial to induce gene expression. However, it remains unknown which components of the SHR-recruited coregulator complex ar...
ORGANISM(S): Homo sapiens (Human) 
2023-10-24 | PXD038902 | Pride
Lc-msms  paxip1  stag2  rime glucocorticoid receptor 
GenomicsA STAG2-PAXIP1/PAGR1 axis suppresses lung tumorigenesis
A STAG2-PAXIP1/PAGR1 axis suppresses lung tumorigenesis
PRJNA1161652 | ENA
GenomicsCharacterization of PAXIP1 in alternative lengthening of telomeres
Characterization of PAXIP1 in alternative lengthening of telomeres
PRJNA1389466 | ENA
GenomicsA STAG2-PAXIP1/PAGR1 axis suppresses lung tumorigenesis [ATAC-Seq]
A STAG2-PAXIP1/PAGR1 axis suppresses lung tumorigenesis [ATAC-Seq]
PRJNA1145398 | ENA
GenomicsA STAG2-PAXIP1/PAGR1 axis suppresses lung tumorigenesis [RNA-Seq]
A STAG2-PAXIP1/PAGR1 axis suppresses lung tumorigenesis [RNA-Seq]
PRJNA1145399 | ENA
OtherA STAG2-PAXIP1/PAGR1 axis suppresses lung tumorigenesis
The cohesin complex is a critical regulator of gene expression. STAG2 is the most frequently mutated cohesin subunit across several cancer types and is a key tumor suppressor in lung cancer. Here, we coupled somatic CRISPR-Cas9 genome editing and tumor barcoding with an autochthonous oncogenic KRAS-...
ORGANISM(S): Mus musculus 
2024-10-22 | GSE277290 | GEO
GenomicsA STAG2-PAXIP1/PAGR1 axis suppresses lung tumorigenesis [ATAC-Seq]
The cohesin complex is a critical regulator of gene expression. STAG2 is the most frequently mutated cohesin subunit across several cancer types and is a key tumor suppressor in lung cancer. Here, we coupled somatic CRISPR-Cas9 genome editing and tumor barcoding with an autochthonous oncogenic KRAS-...
ORGANISM(S): Mus musculus 
2024-10-22 | GSE274205 | GEO
TranscriptomicsA STAG2-PAXIP1/PAGR1 axis suppresses lung tumorigenesis [RNA-Seq]
The cohesin complex is a critical regulator of gene expression. STAG2 is the most frequently mutated cohesin subunit across several cancer types and is a key tumor suppressor in lung cancer. Here, we coupled somatic CRISPR-Cas9 genome editing and tumor barcoding with an autochthonous oncogenic KRAS-...
ORGANISM(S): Mus musculus 
2024-10-22 | GSE274204 | GEO
TranscriptomicsCharacterization of PAXIP1 in alternative lengthening of telomeres
Telomere length maintenance is essential for cellular immortalization and tumorigenesis. About 10% − 15% of human cancers rely on the recombination-based alternative lengthening of telomeres (ALT) to sustain their replicative immortality, yet the underlying molecular mechanism remains incompletely u...
ORGANISM(S): Homo sapiens 
2026-01-01 | GSE314012 | GEO
UnknownThe HOXD9-mediated PAXIP1-AS1 regulates gastric cancer progression through PABPC1/PAK1 modulation.
Not available
S-EPMC10209196 | biostudies-literature
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