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ProteomicsQuantitative fragmentomics to map affinities of interactomes
~500,000 protein interactions have been identified in human but most binding affinities remain unknown, limiting quantitative investigation of interactome-function relationships. This gap can be filled by systematically measuring the affinities of minimal interacting protein fragments, the building ...
ORGANISM(S): Homo sapiens (Human) 
2022-10-14 | PXD027743 | Pride
Complexome Pdz Domain-motif interaction Interactome 
TranscriptomicsThe PDZ-binding motif of SARS-CoV envelope protein is a determinant of viral pathogenesis
A recombinant SARS-CoV lacking the envelope (E) protein is attenuated in vivo. Here we report that E protein PDZ-binding motif (PBM), a domain involved in protein-protein interactions, is a major virulence determinant in vivo. Elimination of SARS-CoV E protein PBM by using reverse genetics led to at...
ORGANISM(S): Mus musculus 
2014-10-31 | E-GEOD-52920 | biostudies-arrayexpress
UnknownPharmacophore Modeling and Molecular Docking Studies of potential inhibitors to E6 PBM-PDZ from Human Papilloma Virus (HPV).
Not available
S-EPMC4574123 | biostudies-literature
UnknownStructural insight into the Scribble PDZ domains interaction with the oncogenic Human T-cell lymphotrophic virus-1 (HTLV-1) Tax1 PBM.
Not available
S-EPMC10952772 | biostudies-literature
ProteomicsBioID proximity proteomics of wild-type and ΔPDZ DVL2 in HEK293 Flp-In T-REx cells
This dataset supports a study investigating how the PDZ domain of Dishevelled-2 (DVL2) specifies β-catenin-independent Wnt signalling outputs. BioID proximity labelling was performed in HEK293 Flp-In T-REx cells stably expressing BirA*-tagged wild-type DVL2 or a matched DVL2 mutant lacking the PDZ d...
ORGANISM(S): Homo sapiens (Human) 
2026-09-12 | PXD079793 | Pride
Bioid  proximity labelling  proximity proteomics  dvl2  dishevelled  pdz domain  daple  girdin  girdin-l  wnt signalling  wnt5a  primary cilia  basal body  pdz-pbm interaction  lc-ms/ms  bottom-up proteomics  data-dependent acquisition  hek293 flp-in t-rex 
UnknownHTRF-based identification of small molecules targeting SARS-CoV-2 E protein interaction with ZO-1 PDZ2.
Not available
S-EPMC12808273 | biostudies-literature
UnknownStructural and functional characterization of the PDZ domain of the human phosphatase PTPN3 and its interaction with the human papillomavirus E6 oncoprotein.
Not available
S-EPMC6520365 | biostudies-literature
UnknownMolecular basis of the interaction of the human tyrosine phosphatase PTPN3 with the hepatitis B virus core protein.
Not available
S-EPMC7806630 | biostudies-literature
UnknownStructural Basis of Highly Specific Interaction between Nephrin and MAGI1 in Slit Diaphragm Assembly and Signaling.
Not available
S-EPMC6115659 | biostudies-literature
UnknownA new crucial protein interaction element that targets the adenovirus E4-ORF1 oncoprotein to membrane vesicles.
Not available
S-EPMC1900153 | biostudies-literature
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