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ProteomicsPPR proteins in Arabidopsis mitoribosomes
Investigation of the protein composition of mitoribosomal subunits in Arabidopsis thaliana by complexome profiling
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2019-04-30 | PXD011088 | Pride
Mitoribosomal subunits Ppr proteins Mitoribosomes Complexome profiling 
ProteomicsProtein exchange rates within mitochondrial protein complexes of differentiated myotubes using pulsed SILAC complexome profiling
We studied dynamics within stable mitochondrial complexes in differentiated mouse myotubes by pulsed SILAC complexome profiling.
ORGANISM(S): Mus musculus (Mouse) 
2020-03-05 | PXD017465 | Pride
Complex i Mitochondria Lc-msms Complexome profiling 
ProteomicsMultiplexed complexome profiling using tandem mass tags
Complexome profiling is a rapidly spreading, powerful approach to gain insight into the nature of protein complexes. It identifies and quantifies protein complexes separated into multiple fractions of increasing molecular mass using mass spectrometry-based, label-free bottom-up proteomics. Complexom...
ORGANISM(S): Homo sapiens (Human) 
2021-08-20 | PXD023211 | Pride
Complexome profiling  multiplexed complexomics  tandem mass tags  protein complexes 
ProteomicsComplexome profiling of mitochondrial protein complexes from patients with mutation in NDUFAF8 gene
NDUFAF8 is an assembly factor of the NADH:ubiquinone oxidoreductase (complex I). Here we used complexome profiling the functional consequences of NDUFAF8 mutations in patient fibroblasts.
ORGANISM(S): Homo sapiens (Human) 
2020-03-05 | PXD015749 | Pride
Oxidative phosphorylation system Lc-msms Complexome profiling Complex i assembly 
ProteomicsComplexome profiling of mitochondrial protein complexes from patients with mutation in NDUFC2 gene
NDUFC2 is a subunit of the membrane part of NADH:ubiquinone oxidoreductase (complex I). Here we used complexome profiling to study the role of NDUFC2 in complex I stability and assembly.
ORGANISM(S): Homo sapiens (Human) 
2020-08-10 | PXD014936 | Pride
Oxidative phosphorylation system Lc-msms Complexome profiling Complex i assembly 
ProteomicsComplexome profiling to study assembly of complex III in heart tissue from UQCRH deficient mice
UQCRH, also called the hinge protein, is a small subunit of Ubiquinol—cytochrome-c reductase (complex III). Here we used a complexome analysis of heart tissue of UQCRH deficient mice to study complex III assembly and altered supercomplex composition.
ORGANISM(S): Mus musculus (Mouse) 
2021-09-20 | PXD022855 | Pride
Oxidative phosphorylation system Supercomplex formation and stability Complexome profiling Complex iii assembly 
ProteomicsComplexome profiling of mitochondrial protein complexes to study the molecular consequences of DNAJC30 mutations in HEK cells
We identified the chaperone DNAJC30 as an important factor to maintain NADH:ubiquinone oxidoreductase (complex I) activity. In this complexome analysis we analysed complexes of the oxidative phosphorylation system (OXPHOS) in HEK cells deficient for DNAJC30.
ORGANISM(S): Homo sapiens (Human) 
2021-09-09 | PXD022340 | Pride
Oxidative phosphorylation system Lc-msms Complexome profiling Complex i maintenance Complex i assembly 
ProteomicsComplexome profiling of mitochondrial protein complexes to study the molecular consequences of DNAJC30 mutations
We identified the chaperone DNAJC30 as an important factor to maintain NADH:ubiquinone oxidoreductase (complex I) activity. In this complexome analysis we detected DNAJC30 in substoichiometric amounts attached to respiratory supercomplexes (I/III2/IVn and demonstrate an accumulation of complex I con...
ORGANISM(S): Homo sapiens (Human) 
2021-09-09 | PXD021385 | Pride
Oxidative phosphorylation system Lc-msms Complexome profiling Complex i maintenance Complex i assembly 
ProteomicsComplexome profiling of mitochondrial protein complexes to study assembly of complex III and supercomplex stability in patients with defects in UQCRH gene
UQCRH, also called the hinge protein, is a small subunit of Ubiquinol—cytochrome-c reductase (complex III). Here we used a complexome analysis of primary and immortalized fibroblasts from patients with a homozygous 2 exon deletion in the UQCRH gene and analyzed complex III assembly and altered supe...
ORGANISM(S): Homo sapiens (Human) 
2021-09-20 | PXD022856 | Pride
Oxidative phosphorylation system Complexome profiling Supercomplexes Complex iii assembly 
ProteomicsComplexome profiling of subcellular fractions of Plasmodium falciparum gametocytes
The aim of the experiment was to get a better understanding of the complexome of Plasmodium falciparum gametocytes and its subcellular distribution. To do so we, whole parasite cells were isolated and subjected to nitrogen cavitation to free cellular content and homogenize the sample. To decrease sa...
ORGANISM(S): Plasmodium falciparum 
2024-10-17 | PXD050751 | Pride
Lc-msms Complexome profiling Plasmodium falciparum 
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