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MetabolomicsProbiotic properties of Pediococcus acidilactici Z123 and its intervention effects and mechanisms on hypercholesterolemia in mice

The intervention effects and underlying mechanisms of Lactobacillus strains against hypercholesterolemia in mice have been extensively documented. However, fewer studies have focused on the cholesterol-lowering potential and the corresponding metabolic regulatory mechanisms of Pediococcus acidila...

2026-06-13 | MTBLS14733 | MetaboLights
MetabolomicsBioconversion properties and anti-hyperuricemic capacity of urate-lowering probiotic fermented Aronia melanocarpa (black chokeberry) beverage

Hyperuricemia (HUA) is a global metabolic disorder characterized by abnormally elevated serum uric acid (UA) (SUA) level, and this study aimed to design a functional fermented beverage based on the urate-lowering probiotic Lactobacillus paracasei N1115 (LP) and Aronia melanocarpa (black chokeberr...

2025-11-28 | MTBLS13414 | MetaboLights
TranscriptomicsRegulation of Pattern Recognition Receptors by the Apolipoprotein A-I Mimetic Peptide 4F
The apolipoprotein A-I (apoA-I) mimetic peptide 4F displays prominent anti-inflammatory properties, including the ability to reduce vascular macrophage content. Macrophages are a heterogenous group of cells, represented by two principal phenotypes, the classically activated M1 macrophage and an alt...
ORGANISM(S): Homo sapiens 
2012-09-30 | E-GEOD-36933 | biostudies-arrayexpress
TranscriptomicsRescue Of Dysfunctional Autophagy By Peptide IDR-1018 Attenuates Hyperinflammatory Phenotype Of Cystic Fibrosis Cells (RNA-seq)
Genome-wide gene expression was measured in peripheral blood mononuclear cells (PBMCs) from patients with cystic fibrosis (CF) after treatment in vitro with the flagellin protein fliC, and/or synthetic peptide IDR-1018 to assess patterns of gene expression. The patterns of gene expression suggest th...
ORGANISM(S): Homo sapiens 
2012-11-20 | E-GEOD-35394 | biostudies-arrayexpress
GenomicsThe identification of a SARs-CoV2 S1 protein derived peptide with super-antigen-like stimulatory properties on T-cells
The identification of a SARs-CoV2 S1 protein derived peptide with super-antigen-like stimulatory properties on T-cells
PRJNA1182358 | ENA
ProteomicsConfident identification of citrullination and carbamylation assisted by peptide retention time prediction
We used 2D-LC-MS/MS methods to examine the impact of the biologically important PTM citrullination and its analogue carbamylation on peptide retention. Three first-dimension separation systems were evaluated: high-pH, HILIC and SCX, with the instrument interface separation happening at low-pH RP for...
ORGANISM(S): Bos Taurus (ncbitaxon:9913) Sus Scrofa (ncbitaxon:9823) Gallus Gallus (ncbitaxon:9031) Homo Sapiens (ncbitaxon:9606) Mus Musculus (ncbitaxon:10090) 
MSV000086214 | MassIVE
UnknownSpiropyran as Building Block in Peptide Synthesis and Modulation of Photochromic Properties.
Not available
S-EPMC11650765 | biostudies-literature
ProteomicsSPE optimization for peptide sample preparation for urine peptidomics
Development of a modified solid phase extraction (SPE) approach for improved peptide yield and analysis sensitivity with LC-MS based peptidomics of urine.
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2016-08-23 | MSV000080086 | MassIVE
TranscriptomicsTranscription profiling of endotoxin-stimulated human monocytic cells in presence and absence of host defense peptide LL-37
The objective of the study was to evaluate transcriptional response of endotoxin-stimulated human monocytic cells in presence and absence of host defense peptide LL-37. A functional genomics approach was used to establish a temporal transcriptional profile and identify differentially expressed gene...
ORGANISM(S): Homo sapiens 
2006-08-01 | E-FPMI-4 | biostudies-arrayexpress
UnknownModulation of the antagonistic properties of an insulin mimetic peptide by disulfide bridge modifications.
Not available
S-EPMC10909431 | biostudies-literature
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