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TranscriptomicsTranscriptomic responses in Arabidopsis thaliana to PIPL3 peptide treatment
In order to investigate possible roles of IDL and PIP/PIPL peptides, the transcriptomic response of Arabidopsis seedlings to treatment with PIPL3 peptide was analysed. PIPL3 (At4g37295) was chosen, as no functional data was available for this peptide; furthermore, PIPL3 was expressed in leaf tissue ...
ORGANISM(S): Arabidopsis thaliana 
2015-07-10 | E-GEOD-66201 | biostudies-arrayexpress
TranscriptomicsToxin-antitoxin of Rickettsia determines fatal addiction of the host cells
Rickettsia spp. can cause mild to severe human disease. These intracellular bacteria are associated with arthropods, nematodes and trematodes, and usually, are efficiently transmitted transovarially to the progeny of the invertebrate host. We recently demonstrated foreign gene acquisition by lateral...
ORGANISM(S): Homo sapiens 
2012-05-23 | E-GEOD-22072 | biostudies-arrayexpress
ProteomicsIdentification of Unknown Biological Toxin Protein Using Mass Spectrometry: A Case Study on De Novo Sequencing of Ricin
Currently, the genomes of many toxin proteins remain unsequenced. Characterizing these toxin proteins and their active peptide segments is crucial for the development of detoxification agents and for discovering proteins with potential therapeutic applications. Existing methods for identifying and d...
ORGANISM(S): Ricinus communis 
2025-12-01 | PXD061213 | Pride
Unknown biological toxin protein Heuristic denovo protein sequencing Ricin toxin De novo sequencing Mass spectrometry 
TranscriptomicsThe IDA-LIKE peptides IDL6 and IDL7 are negative modulators of stress responses in Arabidopsis thaliana
We present a functional characterisation of two members of the IDA-LIKE (IDL) peptide family in Arabidopsis thaliana, IDL6 and IDL7. They are processed both C- and N-terminally to produce active peptides. Structure analyses of synthesized IDL6 and IDL7 peptides indicate that they lack secondary stru...
ORGANISM(S): Arabidopsis thaliana 
2016-03-31 | E-GEOD-77467 | biostudies-arrayexpress
ProteomicsMajor determinants of airway epithelial cell sensitivity to S. aureus alpha-toxin: Disposition of toxin heptamers by extracellular vesicle formation and lysosomal degradation
Alpha-toxin is a major virulence factor of Staphylococcus aureus and plays an important role in S. aureus-induced pneumonia. Different sensitivities toward the toxin of various host cell types have been observed. In this study we investigated internalization of pore-containing areas of the plasma me...
ORGANISM(S): Homo sapiens (Human) 
2021-04-20 | PXD023678 | Pride
Cellular sensitivity Alpha-toxin Airway epithelial cells Virulence factors Staphylococcus aureus Transmembrane pores 
UnknownBibliometric Review of the Literature on Cone Snail Peptide Toxins from 2000 to 2022.
Not available
S-EPMC10058278 | biostudies-literature
ProteomicsPertussis toxin-catalyzed auto- and trans-ADP-ribosylation
This dataset was created to identify amino acids in pertussis toxin ADP-ribosyltransferase subunit (PtxS1) that get auto-modified during catalysis. In parallel, amino acids that get ADP-ribosylated by PtxS1 in the host cell target protein, G-protein inhibitory alpha subunit, were identified.
ORGANISM(S): Homo sapiens (Human) Bordetella pertussis (strain Tohama I / ATCC BAA-589 / NCTC 13251) 
2025-05-06 | PXD050185 | Pride
Pertussis toxin Adp-ribosylation 
ProteomicsStaphylococcus aureus toxin-antitoxin system
Type I toxin-antitoxin (TA) systems are widespread genetic modules in bacterial genomes. They express toxic peptides whose overexpression leads to growth arrest or cell death, whereas antitoxins regulate the expression of toxins, acting as labile antisense RNAs. The Staphylococcus aureus (S. aureus)...
ORGANISM(S): Staphylococcus aureus 
2021-07-05 | PXD023449 | Pride
S. aureus  toxin-antitoxin system  proteomics  cell death 
Genomics
Survival-based screening for peptide inhibitors of E. coli toxin RelE
PRJNA1252724 | ENA
TranscriptomicsTranscriptional profiling of miRNA in CD4+ T-cells from brain of EAE+Vehicle and EAE+DIM mice
C57BL/6 mice were immunized by subcutaneous injection of MOG35-55 peptide.DIM post-treatment was given at DAY 10 of the disease progression. CD4 T cells were isolated from the brain of the mice on day 15 of the MOG35-55 peptide immunization. Total RNA was extracted and subjected to microRNA high-...
ORGANISM(S): Mus musculus 
2013-11-01 | E-MTAB-2026 | biostudies-arrayexpress
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