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ProteomicsMajor determinants of airway epithelial cell sensitivity to S. aureus alpha-toxin: Disposition of toxin heptamers by extracellular vesicle formation and lysosomal degradation
Alpha-toxin is a major virulence factor of Staphylococcus aureus and plays an important role in S. aureus-induced pneumonia. Different sensitivities toward the toxin of various host cell types have been observed. In this study we investigated internalization of pore-containing areas of the plasma me...
ORGANISM(S): Homo sapiens (Human) 
2021-04-20 | PXD023678 | Pride
Cellular sensitivity Alpha-toxin Airway epithelial cells Virulence factors Staphylococcus aureus Transmembrane pores 
TranscriptomicsThe epithelial cell transcriptome after alpha-toxin treatment
Responsiveness of cells to alpha-toxin (Hla) from Staphylococcus aureus appears to occur in a cell-type dependent manner. Here, we compare two human bronchial epithelial cell lines, i.e. Hla-susceptible 16HBE14o- and Hla-resistant S9 cells, by a quantitative multi-omics strategy for a better underst...
ORGANISM(S): Homo sapiens 
2015-03-31 | E-GEOD-65018 | biostudies-arrayexpress
ProteomicsInhibition of tumour necrosis factor alpha by Etanercept attenuates Shiga toxin-induced brain pathology
Infection with enterohemorrhagic E. coli (EHEC) causes severe changes in the brain leading to angiopathy, encephalopathy and microglial activation. In this study, we investigated the role of tumour necrosis factor alpha (TNF-α) for microglial activation and brain pathology using a preclinical mouse ...
ORGANISM(S): Mus musculus (Mouse) 
2025-02-18 | PXD052925 | Pride
Microglial activation Brain pathology Tnfα (tumour necrosis factor alpha) Etanercept Ehec (enterohemorrhagic e. coli) 
ProteomicsEnhanced Staphylococcus aureus vaccine protection by uncoupling of the alpha-toxin-ADAM10 interaction
Staphylococcus aureus is the leading global cause of bacterial infection-associated mortality, as vaccine development has been elusive. S. aureus alpha-toxin (Hla) is an essential virulence factor in disease. In children, the anti-Hla neutralizing antibody response is the only known correlate of hum...
ORGANISM(S): Escherichia coli 
2024-08-13 | PXD047859 | Pride
Disulfide bond Lc-ms/ms 
GenomicsBombyx mori strain:Dazao
Bombyx mori response to α-toxin
PRJNA472176 | ENA
UnknownCharacterization of alpha-toxin hla gene variants, alpha-toxin expression levels, and levels of antibody to alpha-toxin in hemodialysis and postsurgical patients with Staphylococcus aureus bacteremia.
Not available
S-EPMC4290928 | biostudies-literature
ProteomicsTwo pairs of back-to-back α-helices of Kingella kingae RtxA toxin are crucial for the formation of a membrane pore
The RtxA cytotoxin, a member of the RTX (Repeats in ToXin) family of pore-forming toxins, is the primary virulence factor of the paediatric facultative pathogen Kingella kingae. Although structure-function studies of RTX toxins have defined their characteristic domains and features, the exact membra...
ORGANISM(S): Kingella sp. (in: b-proteobacteria) 
2025-02-18 | PXD060913 | Pride
Rtx toxins Kingella kingae 
UnknownNaturally occurring Clostridium perfringens nontoxic alpha-toxin variant as a potential vaccine candidate against alpha-toxin-associated diseases.
Not available
S-EPMC100128 | biostudies-literature
UnknownMembrane-Binding Mechanism of Clostridium perfringens Alpha-Toxin.
Not available
S-EPMC4690130 | biostudies-literature
UnknownClostridium perfringens α-toxin impairs erythropoiesis by inhibition of erythroid differentiation.
Not available
S-EPMC5507896 | biostudies-literature
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