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TranscriptomicsTranscription profiling of human moncyte derived dendritic cells grown with/without Etanercept TNF inhibitor
The process for making monocyte derived DCs (moDCs) has been previously described (46). All analysis was performed on “day 5” immature DCs. Etanercept 10mg/mL was added to experimental wells on days 0, 2, and 4. We chose this concentration of etanercept as it approximates the plasma concentra...
ORGANISM(S): Homo sapiens 
2008-06-16 | E-GEOD-9239 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human response to etanercept treatment in patients with Psoriasis
The success of TNF inhibitors for treatment of psoriasis and other inflammatory diseases was previously attributed to blockade of innate immunity. In a clinical trial using etanercept TNF blocking agent to treat psoriasis vulgaris, we used affymetrix gene arrays to analyze broad gene profiles in le...
ORGANISM(S): Homo sapiens 
2009-11-09 | E-GEOD-11903 | biostudies-arrayexpress
TranscriptomicsEarly tissue responses to etanercept in psoriasis lesions
Anti-TNF-alpha therapy has made a significant impact on the treatment of psoriasis. Despite being designed to neutralize TNF-alpha activity, the mechanism of action of these agents in the resolution of psoriasis remains unclear. The aim of this study was to better understand the mechanism of action ...
ORGANISM(S): Homo sapiens 
2014-06-07 | E-GEOD-47751 | biostudies-arrayexpress
TranscriptomicsRNA-sequencing of the small-RNA transcriptome in blood, across three time-points in severe psoriasis patients treated with the tumor necrosis factor (TNF) inhibitor, etanercept
Blood (mRNA and miRNA) and skin mRNA transcriptomes were investigated across three time-points in a pilot investigation of ten severe psoriasis patients, treated with the tumor necrosis factor (TNF) inhibitor, etanercept. We used illumina RNA-sequencing to analyse the small-RNA transcriptome in bloo...
ORGANISM(S): Homo sapiens 
2018-09-21 | E-MTAB-6428 | biostudies-arrayexpress
TranscriptomicsRNA-sequencing of the mRNA transcriptome in lesional and non-lesional skin, across three time-points in severe psoriasis patients treated with the tumor necrosis factor (TNF) inhibitor, etanercept
Blood (mRNA and miRNA) and skin mRNA transcriptomes were investigated across three time-points in a pilot investigation of ten severe psoriasis patients, treated with the tumor necrosis factor (TNF) inhibitor, etanercept. We used illumina RNA-sequencing to analyse the small-RNA transcriptome in bloo...
ORGANISM(S): Homo sapiens 
2018-09-21 | E-MTAB-6556 | biostudies-arrayexpress
TranscriptomicsRNA-sequencing of the mRNA transcriptome in blood, across three time-points in severe psoriasis patients treated with the tumor necrosis factor (TNF) inhibitor, etanercept
Blood (mRNA and miRNA) and skin mRNA transcriptomes were investigated across three time-points in a pilot investigation of ten severe psoriasis patients, treated with the tumor necrosis factor (TNF) inhibitor, etanercept. We used illumina RNA-sequencing to analyse the mRNA transcriptome in blood
ORGANISM(S): Homo sapiens 
2018-10-01 | E-MTAB-6555 | biostudies-arrayexpress
TranscriptomicsEffect of Etanercept on Active Pulmonary Tuberculosis in Rabbits
Treatment of chronic inflammatory diseases with tumor necrosis factor alpha antagonists has been associated with increased risk of tuberculosis (TB). We examined the usefulness of the rabbit model of active pulmonary TB for studying the impact of the human immune modulatory reagent etanercept on the...
ORGANISM(S): Oryctolagus cuniculus 
2014-01-28 | E-GEOD-54442 | biostudies-arrayexpress
TranscriptomicsTranscriptional response of LPS-stimulated monocyte-derived macrophages in the presence or absence of the anti-TNF agonist Etanercept
We measured TNFα activity on the transcriptional level by identifying TNFα-inducible genes in human blood monocyte-derived macrophages (MDM). On the basis that TNFα does not act in isolation, we used bacterial lipopolysaccharide (LPS) as a prototypic model of a stimulus to invoke secretion of a w...
ORGANISM(S): Homo sapiens 
2017-08-04 | E-MTAB-5095 | biostudies-arrayexpress
ProteomicsMulti-level – Intact, Subunits, and Peptides – Characterization of Antibody-Based Therapeutics by a Single-Column LC-MS setup
A comprehensive characterization of biotherapeutics, mandated by regulatory authorities, require analyses of a protein drug at multiple structure levels. Such multi-level characterization can be performed by mass spectrometry (MS), with established conventional MS-based assays of product quality att...
ORGANISM(S): Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus) 
2025-02-26 | PXD054948 | Pride
Subunits Intact Lc-ms Ead C4-column Peptides 
GenomicsBulk RNA-seq on NOD mice prostate tissues treated with etanercept
Bulk RNA-seq on NOD mice prostate tissues treated with etanercept
PRJNA760533 | ENA
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