Background: Oxaliplatin-induced peripheral neuropathy (OIPN) poses a significant challenge for patients with colorectal tumor, often resulting in treatment interruption or discontinuation and subsequent treatment failure. Herein, a longitudinal untargeted metabolomic study to reveal the metabolom...

Background: Recent findings from our group indicate that sex differences in Parkinson's disease (PD) patients with idiopathic conditions or carrying pathogenic mutations significantly influence the blood occurrence of D and L-amino acids, lipids, antioxidants, and energy-related metabolites when ...

Blood plays a vital role in diagnostic medicine by providing essential information for assessing health and diagnosing various conditions. Routine blood tests can reveal important biomarkers that support early diagnosis and timely intervention. Recently, extracellular vesicles (EVs) have emerged ...

Accurate oestrus detection is critical for optimizing reproductive efficiency in beef cattle, yet the underlying metabolic and microbial mechanisms remain poorly understood, particularly in Simmental cattle. To address this gap, we employed an integrated metabolomics and microbiome approach ...

Intracerebral hemorrhage (ICH) is a severe neurological disorder with high mortality and disability. Using LC-MS, we profiled serum metabolites from 20 patients with and without ICH, identifying 3,178 metabolites. ICH samples were enriched in benzene derivatives (15.63%), organic acids (12.47%), ...

This study applied serum metabolomics to compare patients with cerebral infarction (n=10) and controls (n=10). A total of 3,160 metabolites were identified, with distinct class distributions between groups. Cerebral infarction patients showed elevated benzene derivatives, organic acids, and bile ...