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ProteomicsIKK Promotes Cytokine-Induced and Cancer-Associated AMPK Activity and Attenuates Phenformin-Induced Cell Death in LKB1-Deficient Cells
The 5' AMP-activated protein kinase (AMPK) is a master energy sensing kinase that is regulated by phosphorylation of Thr172 in its activation loop. Three kinases can phosphorylate AMPK at Thr172: the tumor suppressor LKB1, CAMKK2 and TAK1. While LKB1- and CAMKK2-mediated AMPK Thr172 phosphorylatio...
ORGANISM(S): Homo sapiens (Human) 
2018-07-16 | PXD009897 | Pride
Ikk ampk  inflammation  il-1  phenformin 
TranscriptomicsMicroarray gene expression analysis of human melanoma A375 cells resistant to 0.5mM phenformin against sensitive naive cells.
The aim of this study was to generate an easy-to-reproduce, on-off in vitro model of metabolic switch in melanoma that can be used as a tool for the study of metabolic reprogramming under stress conditions, therapeutic pressure or microenvironmental changes. Experimentally, we forced melanoma cells...
ORGANISM(S): Homo sapiens 
2018-11-01 | E-MTAB-6663 | biostudies-arrayexpress
TranscriptomicsMicroarray gene expression analysis of human melanoma A375 cells treated with 0.5mM phenformin against untreated control
The aim of this study was to characterize the effect of phenformin on human melanoma cells at the transcritpional level. Experimentally, A375 cells have been treated or untreated with 0.5mM phenformin for 72h, then lysed for RNA isolation.
ORGANISM(S): Homo sapiens 
2018-11-01 | E-MTAB-6665 | biostudies-arrayexpress
GenomicsExpression data from livers of rats with and without phenformin treatment
Expression data from livers of rats with and without phenformin treatment
PRJNA505708 | ENA
UnknownPhenformin Promotes Keratinocyte Differentiation via the Calcineurin/NFAT Pathway.
Not available
S-EPMC8179313 | biostudies-literature
UnknownPhenformin as an Anticancer Agent: Challenges and Prospects.
Not available
S-EPMC6651400 | biostudies-literature
GenomicsExpression data from hearts (left ventricle apex) of rats with and without phenformin treatment
Expression data from hearts (left ventricle apex) of rats with and without phenformin treatment
PRJNA505709 | ENA
GenomicsGene expression signatures of A2058 cells treated with neopetasin, metformin, and phenformin
Gene expression signatures of A2058 cells treated with neopetasin, metformin, and phenformin
PRJNA631798 | ENA
TranscriptomicsTranscription profiling of liver from mice treated with phenformin, meformin or methyl cellulose
Comparison of mouse liver responses between phenformin and metformin
ORGANISM(S): Mus musculus 
2008-10-30 | E-MEXP-1302 | biostudies-arrayexpress
UnknownRepurposing phenformin for the targeting of glioma stem cells and the treatment of glioblastoma.
Not available
S-EPMC5302927 | biostudies-literature
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