Sort   by:  
 Page size 
TranscriptomicsMicroarray data of human leukemia cells MV4;11 with or without IKK inhibitor treatment.
MLL fusion proteins in leukemia induce aberrant transcriptional elongation and associated chromatin perturbations, however the upstream signaling pathways and activators that recruit or retain MLL oncoproteins at initiated promoters are unknown. Through functional and comparative genomic studies, we...
ORGANISM(S): Homo sapiens 
2013-09-19 | E-GEOD-46251 | biostudies-arrayexpress
ProteomicsIKK Promotes Cytokine-Induced and Cancer-Associated AMPK Activity and Attenuates Phenformin-Induced Cell Death in LKB1-Deficient Cells
The 5' AMP-activated protein kinase (AMPK) is a master energy sensing kinase that is regulated by phosphorylation of Thr172 in its activation loop. Three kinases can phosphorylate AMPK at Thr172: the tumor suppressor LKB1, CAMKK2 and TAK1. While LKB1- and CAMKK2-mediated AMPK Thr172 phosphorylatio...
ORGANISM(S): Homo sapiens (Human) 
2018-07-16 | PXD009897 | Pride
Ikk ampk  inflammation  il-1  phenformin 
TranscriptomicsMicroarray data of mouse MLL-AF10 leukemia cells with or without IKK inhibitor treatment
MLL fusion proteins in leukemia induce aberrant transcriptional elongation and associated chromatin perturbations, however the upstream signaling pathways and activators that recruit or retain MLL oncoproteins at initiated promoters are unknown. Through functional and comparative genomic studies, we...
ORGANISM(S): Mus musculus 
2013-09-19 | E-GEOD-46250 | biostudies-arrayexpress
TranscriptomicsTranscription of Tnfaip3 is regulated by NF-kB and p38 via C/EBPβ in activated macrophages
Macrophages play a pivotal role in the immune system through recognition and elimination of microbial pathogens. Toll-like receptors (TLRs) on macrophages interact with microbial substances and initiate signal transduction through intracellular adapters. TLR4, which is important for the response to ...
ORGANISM(S): Mus musculus 
2015-04-28 | E-GEOD-46361 | biostudies-arrayexpress
GenomicsIKK in mesothelioma
IKK in mesothelioma
PRJNA533336 | ENA
TranscriptomicsThe Notch/Hes1 pathway sustains NF-M-NM-:B activation through CYLD repression in T cell leukemia
The NF-M-NM-:B pathway is a critical regulator of the immune system and has been implicated in cellular transformation and tumorigenesis. NF-M-NM-:B response is regulated by the activation state of the IM-NM-:B kinase (IKK) complex and triggered by a wide spectrum of stimuli. We previously reported ...
ORGANISM(S): Homo sapiens 
2011-05-07 | E-GEOD-20667 | biostudies-arrayexpress
TranscriptomicsMicroarray data of leukemia cells with or without IKK inhibitor treatment
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Mus musculus 
2013-09-19 | E-GEOD-46252 | biostudies-arrayexpress
TranscriptomicsBlockade of oncogenic IkappaB kinase activity in ABC DLBCL by small molecule BET protein inhibitors
In the activated B cell-like (ABC) subtype of diffuse large B cell lymphoma (DLBCL), NF-kappaB activity is essential for viability of the malignant cells and is sustained by constitutive activity of IkappaB kinase (IKK) in the cytoplasm. Here, we report an unexpected role for the bromodomain and ext...
ORGANISM(S): Homo sapiens 
2014-08-01 | E-GEOD-58791 | biostudies-arrayexpress
ProteomicsA novel YDDX linear motif mediates docking of the IKK kinase to substrates: structural and functional insights
The inhibitor of kB kinase (IKK) is the master regulator of the nuclear factor kB (NF-kB) pathway, involved in inflammatory, immune and apoptotic responses. In the ‘canonical’ NF-kB pathway, IKK phosphorylates inhibitor of kB (IkB) proteins and this triggers ubiquitin-mediated degradation of IkB, le...
ORGANISM(S): Homo Sapiens (human) 
2024-05-09 | PXD037534 | JPOST Repository
TranscriptomicsIKKe coordinates invasion and metastasis
IKKe was identified previously as a breast cancer oncogene and was associated with poor clinical outcome in ovarian cancer. In order to elucidate functional roles of IKKe, we used microarray analysis to identify genes changed upon IKKe shRNA knockdown and compared with genes affected in ovarian canc...
ORGANISM(S): Homo sapiens 
2012-11-16 | E-GEOD-42320 | biostudies-arrayexpress
Sort   by:  
 Page size