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TranscriptomicsPhosphatidylinositol 3-Kinase (PI3K) Signaling via Glycogen Synthase Kinase-3 (Gsk-3) Regulates DNA Methylation of Imprinted Loci.
The two vertebrate Gsk-3 isoforms, Gsk-3a and Gsk-3b, are encoded by distinct genetic loci and exhibit mostly redundant function in murine embryonic stem cells (ESCs). Here we report that deletion of both Gsk-3a and Gsk-3b in mouse ESCs results in misregulated expression of imprinted genes and hypom...
ORGANISM(S): Mus musculus 
2010-11-15 | E-GEOD-20015 | biostudies-arrayexpress
ProteomicsAdenovirus E4ORF1 activates isoform-specific phosphatidylinositol 3-kinase signaling
The human adenovirus serotype 5 E4ORF1 (Ad5E4ORF1) protein promotes primary endothelial cell survival and angiocrine functions by hijacking the cellular phosphatidylinositol 3-kinase (PI3K)/AKT signaling pathway. However, the mechanism by which E4ORF1 activates PI3K in vascular cells remains largely...
ORGANISM(S): Homo sapiens (Human) 
2026-01-05 | PXD069348 | Pride
Adenovirus  akt  angiogenesis  dlg1  e4orf1  endothelium  phosphatidylinositol-3-kinase. 
TranscriptomicsTranscription profiling of human HCMV-Infected monocytes
Human cytomegalovirus induces a pro-inflammatory monocyte following infection and we have evidence that NF-κB and phosphatidylinositol 3-kinase [PI(3)K] are key mediators in this early activation. To begin to address how these signalling pathways are responsible for the rapid activation of infecte...
ORGANISM(S): Homo sapiens 
2008-06-16 | E-GEOD-9601 | biostudies-arrayexpress
ProteomicsRab5a-VPS34 unnatural amino acid mediated crosslinking
The small GTPase Rab5 has an essential role in sorting vesicles arriving to and leaving the early endosome. One key function of Rab5 in this process is the activation of the primordial phosphatidylinositol 3-kinase VPS34, a lipid kinase that phosphorylates phosphatidylinositol (PI) to generate PI3P....
ORGANISM(S): Homo Sapiens (human) 
2021-12-21 | PXD023533 | JPOST Repository
GenomicsPhosphatidylinositol 3-Kinase (PI3K) delta blockade increases genomic instability in B cells
Phosphatidylinositol 3-Kinase (PI3K) delta blockade increases genomic instability in B cells
PRJNA311552 | ENA
ProteomicsLabel-free quantitative plasma membrane proteome analysis of Candida glabrata wild-type and Cgvps34∆ (lacks phosphatidylinositol 3- phosphate kinase, CgVps34) strains. Label-free quantitative plasma membrane proteome analysis of Candida glabrata wild-type and Cgvps34∆ (lacks phosphatidylinositol 3- phosphate kinase, CgVps34) strains.
The project is aimed at characterizing the effect of loss of phosphatidylinositol 3- phosphate kinase (CgVps34) on the plasma membrane proteome of Candida glabrata.
ORGANISM(S): Candida glabrata (Yeast) (Torulopsis glabrata) 
2024-02-19 | PXD042056 | Pride
Plasma membrane (pm) Pi3k (phosphatidylinositol 3- phosphate kinase) Candida glabrata Label-free quantitative proteome analysis 
TranscriptomicsTranscription profiling of neuronal differentiation in two subtypes of SH-SY5Y
Background: SH-SY5Y cells exhibit a neuronal phenotype when treated with all-trans retinoic acid (RA), but the molecular mechanism of activation in the signaling pathway mediated by phosphatidylinositol 3-kinase (PI3K) is not sufficiently understood. To shed new light on the mechanism, we comprehens...
ORGANISM(S): Homo sapiens 
2009-09-04 | E-GEOD-9169 | biostudies-arrayexpress
TranscriptomicsMolecular pharmacology of phosphatidylinositol 3-kinase inhibition in human glioma
Gliomas are primary brain tumors with poor prognosis that exhibit frequent abnormalities in phosphatidylinositol 3-kinase (PI3 kinase) signaling. We investigated the molecular mechanism of action of the isoform-selective class I PI3 kinase and mTOR inhibitor PI-103 in human glioma cells. The potent ...
ORGANISM(S): Homo sapiens 
2009-04-21 | GSE12175 | GEO
GenomicsPhosphatidylinositol-3 kinase signaling controls survival and stemness of hematopoietic stem and progenitor cells
Phosphatidylinositol-3 kinase signaling controls survival and stemness of hematopoietic stem and progenitor cells
PRJNA702191 | ENA
UnknownDevelopment of selective inhibitors of phosphatidylinositol 3-kinase C2α.
Not available
S-EPMC7613998 | biostudies-literature
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