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ProteomicsAn organ-specific angiogenic control mechanism for endothelial tailoring.
Each organ of the human body requires locally-adapted blood vessels1–3. The gain of such organotypic vessel specializations is often deemed molecularly unrelated to the process of organ vascularization. Opposing this model, we reveal a molecular mechanism for brain-specific angiogenesis that operate...
ORGANISM(S): Homo sapiens (Human) 
2024-02-08 | PXD042613 | Pride
Angiogenesis  tip cell angiodiversity  wnt/β-catenin signaling  blood-brain barrier  bbb  mmp25  col4a5  col4a6  pial fibroblast  gpr124  reck  wnt7a 
TranscriptomicsSingle cell transcriptomic analyses of the developing meninges reveal meningeal fibroblast diversity and function
The meninges are a multilayered structure composed of fibroblasts, blood and lymphatic vessels, and immune cells. Meningeal fibroblasts secrete a variety of factors that control CNS development, yet strikingly little is known about their heterogeneity or development. Using single cell sequencing, we...
ORGANISM(S): Mus musculus 
2020-07-06 | GSE150219 | GEO
GenomicsSingle cell transcriptomic analyses of the developing meninges reveal meningeal fibroblast diversity and function
Single cell transcriptomic analyses of the developing meninges reveal meningeal fibroblast diversity and function
PRJNA631534 | ENA
UnknownSingle-Cell Transcriptomic Analyses of the Developing Meninges Reveal Meningeal Fibroblast Diversity and Function.
Not available
S-EPMC7769050 | biostudies-literature
UnknownA brain-specific angiogenic mechanism enabled by tip cell specialization.
Not available
S-EPMC11041701 | biostudies-literature
UnknownExercise induces cerebral VEGF and angiogenesis via the lactate receptor HCAR1.
Not available
S-EPMC5457513 | biostudies-literature
TranscriptomicsUsing Oligo Array Analysis to Determine Genes of Importance in the Meninges and Associated Vasculature Function and their Sensitivity to Amphetamine Toxicity
Oligo array analysis with bioinformatics tools identified genes with very high expression levels in the meninges, arachnoid and pial membranes, and associated vasculature (MAV) as potentially important and unique to these tissues in rat. It was also determined whether these genes were more sensitiv...
ORGANISM(S): Rattus norvegicus 
2010-08-24 | E-GEOD-23093 | biostudies-arrayexpress
GenomicsPdgfragene inactivation mediates tissue remodeling in hypomyelinated cerebral cortex
Pdgfragene inactivation mediates tissue remodeling in hypomyelinated cerebral cortex
PRJNA1134736 | ENA
TranscriptomicsGenes Required for and Effects of Inducible Alginate Overproduction by Growth of Pseudomonas aeruginosa on PIAAMV
Pseudomonas aeruginosa is an opportunistic pathogen that can adapt to changing environments and can secrete an exopolysaccharide known as alginate as a protection response resulting in a colony morphology and phenotype referred to as mucoid. However how P. aeruginosa senses its environment and acti...
ORGANISM(S): Pseudomonas aeruginosa 
2013-07-15 | E-GEOD-48429 | biostudies-arrayexpress
TranscriptomicsGene expression profiling reveals mast cell-dependent inflammation in the meninges in early EAE.
The meninges are generally considered relatively inert tissues that house the CSF and provide protection for the brain and spinal cord. However, our previous studies using Kit mutant (Kit W/Wv) mast cell-deficient mice demonstrated that mast cells residing in the dura mater and pia mater exacerbate ...
ORGANISM(S): Mus musculus 
2013-01-01 | E-GEOD-37191 | biostudies-arrayexpress
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